Journal article
Untargeted serum metabolomic profiles and breast density in young women
Cancer causes & control, Vol.35(2), pp.323-334
02/2024
DOI: 10.1007/s10552-023-01793-w
PMID: 37737303
Abstract
Purpose of the study
Breast density is an established risk factor for breast cancer. However, little is known about metabolic influences on breast density phenotypes. We conducted untargeted serum metabolomics analyses to identify metabolic signatures associated with breast density phenotypes among young women.
Methods
In a cross-sectional study of 173 young women aged 25–29 who participated in the Dietary Intervention Study in Children 2006 Follow-up Study, 449 metabolites were measured in fasting serum samples using ultra-high-performance liquid chromatography-tandem mass spectrometry. Multivariable-adjusted mixed-effects linear regression identified metabolites associated with magnetic resonance imaging measured breast density phenotypes: percent dense breast volume (%DBV), absolute dense breast volume (ADBV), and absolute non-dense breast volume (ANDBV). Metabolite results were corrected for multiple comparisons using a false discovery rate adjusted p-value (q).
Results
The amino acids valine and leucine were significantly inversely associated with %DBV. For each 1 SD increase in valine and leucine, %DBV decreased by 20.9% (q = 0.02) and 18.4% (q = 0.04), respectively. ANDBV was significantly positively associated with 16 lipid and one amino acid metabolites, whereas no metabolites were associated with ADBV. Metabolite set enrichment analysis also revealed associations of distinct metabolic signatures with %DBV, ADBV, and ANDBV; branched chain amino acids had the strongest inverse association with %DBV (p = 0.002); whereas, diacylglycerols and phospholipids were positively associated with ANDBV (p ≤ 0.002), no significant associations were observed for ADBV.
Conclusion
Our results suggest an inverse association of branched chain amino acids with %DBV. Larger studies in diverse populations are needed.
Details
- Title: Subtitle
- Untargeted serum metabolomic profiles and breast density in young women
- Creators
- Seungyoun Jung - Ewha Womans UniversitySarah Silva - University of Maryland, BaltimoreCher M. Dallal - University of Maryland, College ParkErin LeBlanc - Kaiser Permanente Center for Health ResearchKenneth Paris - Louisiana State UniversityJohn Shepherd - University of Hawaiʻi at MānoaLinda G. Snetselaar - University of IowaLinda Van Horn - Northwestern UniversityYuji Zhang - University of MaryJoanne F. Dorgan - University of Mary
- Resource Type
- Journal article
- Publication Details
- Cancer causes & control, Vol.35(2), pp.323-334
- Publisher
- Springer
- DOI
- 10.1007/s10552-023-01793-w
- PMID
- 37737303
- ISSN
- 0957-5243
- eISSN
- 1573-7225
- Grant note
- name: National Cancer Institute, award: R01CA104670, R01CA214783, P30CA134274; name: State of Maryland Cigarette Restitution Fund
- Language
- English
- Electronic publication date
- 09/22/2023
- Date published
- 02/2024
- Academic Unit
- Epidemiology; Fraternal Order of Eagles Diabetes Research Center; Internal Medicine
- Record Identifier
- 9984468960302771
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