Journal article
Unusual reactivity of acetylacetone with imidazole/histamine complexes and fac -M ( OH 2 ) 3 (CO) 3 + (M = Re, 99mTc)
Inorganica Chimica Acta, Vol.365(1), pp.356-362
2011
DOI: 10.1016/j.ica.2010.09.050
Abstract
The
fac
-M
(CO)
3
+
(M
=
Re,
99mTc) moiety was investigated with a known bidentate ligand, acetylacetone (acac) to generate
fac-Re(CO)
3(acac)(OH
2) followed by the introduction of imidazole based ligands in a 2
+
1 and tridentate approach. Depending on the ligand and reaction conditions, monomer and dimer complexes were isolated.
The
fac
-M
(CO)
3
+
(M
=
Re,
99mTc) moiety was investigated with a known bidentate ligand, acetylacetone (acac) and imidazole based ligands in a 2
+
1 and tridentate approach. In the 2
+
1 approach, the
fac-Re(CO)
3(acac)(OH
2) was reacted with imidazole or 1-methylimidazole to yield a unique anionic μ-bridging imidazol-1-ide dimer
fac-[(imidazol-1-ide)-bis-(
fac-acetylacetonatotricarbonylrhenium (I)],
1, or the monomer version
fac-M(CO)
3(acac)(1-methylimidazole),
2, respectively. Based on the Schiff base condensation of a ketone and a primary amine, a tridentate ligand approach for
fac
-M
(
OH
2
)
3
(CO)
3
+
utilizing the reactivity of acac and histamine was explored in a didactic manner: (1) an
in situ ligand synthesis approach reacting
fac-M(CO)
3(acac)(OH
2) with histamine (2
+
2
=
3) that led to the formation of an unexpected dimer μ-acachistimine, compound,
3, or (2) direct complexation of
fac
-M
(
OH
2
)
3
(CO)
3
+
with the prepared ligand acachistimine,
4, to yield the monomer product
fac-M(CO)
3(acachistimine),
5. The results observed with rhenium complexes characterized by standard chemical analysis and X-ray analysis correlated with the radioactive experiments conducted with
99
m
Tc
(CO)
3
+
.
Details
- Title: Subtitle
- Unusual reactivity of acetylacetone with imidazole/histamine complexes and fac -M ( OH 2 ) 3 (CO) 3 + (M = Re, 99mTc)
- Creators
- Paul D Benny - Department of Chemistry, Washington State University, P.O. Box 644630, Pullman, WA 99164, USAGlenn A Fugate - Department of Chemistry, Washington State University, P.O. Box 644630, Pullman, WA 99164, USATanushree Ganguly - Department of Chemistry, Washington State University, P.O. Box 644630, Pullman, WA 99164, USABrendan Twamley - University Research Office, University of Idaho, Moscow, ID 83844, USADejan-Krešimir Bučar - Department of Chemistry, University of Iowa, Iowa City, IA 52242-1294, USALeonard R MacGillivray - Department of Chemistry, University of Iowa, Iowa City, IA 52242-1294, USA
- Resource Type
- Journal article
- Publication Details
- Inorganica Chimica Acta, Vol.365(1), pp.356-362
- Publisher
- Elsevier B.V
- DOI
- 10.1016/j.ica.2010.09.050
- ISSN
- 0020-1693
- eISSN
- 1873-3255
- Language
- English
- Date published
- 2011
- Academic Unit
- Pharmaceutical Sciences and Experimental Therapeutics; Chemistry
- Record Identifier
- 9984216691402771
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