Journal article
Up-regulation of A-type potassium currents protects neurons against cerebral ischemia
Journal of cerebral blood flow and metabolism, Vol.31(9), pp.1823-1835
09/2011
DOI: 10.1038/jcbfm.2011.88
PMCID: PMC3185888
PMID: 21673715
Abstract
Excitotoxicity is the major cause of many neurologic disorders including stroke. Potassium currents modulate neuronal excitability and therefore influence the pathological process. A-type potassium current (
I
A
) is one of the major voltage-dependent potassium currents, yet its roles in excitotoxic cell death are not well understood. We report that, following ischemic insults, the
I
A
increases significantly in large aspiny (LA) neurons but not medium spiny (MS) neurons in the striatum, which correlates with the higher resistance of LA neurons to ischemia. Activation of protein kinase C
α
increases
I
A
in LA neurons after ischemia. Cultured neurons from transgenic mice lacking both Kv1.4 and Kv4.2 subunits exhibit an increased vulnerability to ischemic insults. Increase of
I
A
by recombinant expression of Kv1.4 or Kv4.2 is sufficient in improving the survival of MS neurons against ischemic insults both
in vitro
and
in vivo
. These results, taken together, provide compelling evidence for a protective role of
I
A
against ischemia.
Details
- Title: Subtitle
- Up-regulation of A-type potassium currents protects neurons against cerebral ischemia
- Creators
- Ping Deng - , Indianapolis, IndianaZhi-Ping Pang - , Indianapolis, IndianaZhigang Lei - , Indianapolis, IndianaSojin Shikano - , Baltimore, MarylandQiaojie Xiong - , Baltimore, MarylandBrandon K Harvey - , Baltimore, MarylandBarry London - , Pittsburgh, PennsylvaniaYun Wang - , Baltimore, MarylandMin Li - , Baltimore, MarylandZao C Xu - , Indianapolis, Indiana
- Resource Type
- Journal article
- Publication Details
- Journal of cerebral blood flow and metabolism, Vol.31(9), pp.1823-1835
- Publisher
- Nature Publishing Group
- DOI
- 10.1038/jcbfm.2011.88
- PMID
- 21673715
- PMCID
- PMC3185888
- ISSN
- 0271-678X
- eISSN
- 1559-7016
- Alternative title
- A-type potassium current and neuroprotection
- Language
- English
- Date published
- 09/2011
- Academic Unit
- Molecular Physiology and Biophysics; Cardiovascular Medicine; Internal Medicine
- Record Identifier
- 9984025427302771
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