Update on Animal Models of Exfoliation Syndrome

Michael G Anderson; Kacie J Meyer; Adam Hedberg-Buenz; John H Fingert

doi:10.1097/IJG.0000000000000911

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Update on Animal Models of Exfoliation Syndrome

Journal article

Peer reviewed

Update on Animal Models of Exfoliation Syndrome

Michael G Anderson, Kacie J Meyer, Adam Hedberg-Buenz and John H Fingert

Journal of glaucoma, Vol.27 Suppl 1(7), pp.S78-S82

07/2018

DOI: 10.1097/IJG.0000000000000911

PMCID: PMC6028301

PMID: 29419647

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https://www.ncbi.nlm.nih.gov/pmc/articles/6028301View

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Abstract

Animal models are powerful tools for studying diseases that affect the eye, such as exfoliation syndrome (XFS). Two types of animal models have been used to investigate the pathophysiology of XFS and glaucoma. One class of models is engineered to have key features of a disease by alteration of their genome (genotype-driven animal models). LOXL1 is the first gene known to increase the risk for developing XFS in humans. Two transgenic mouse models with altered Loxl1 genes have been generated to study XFS. One strain of mice, Loxl1 deficient mice, also known as Loxl1 knockout mice, have had the Loxl1 gene removed from their genomes. Another strain has been engineered to produce excess amounts of the protein produced by the Loxl1 gene, or Loxl1 overexpression. A second class of animal models includes naturally occurring strains of mice that exhibit key clinical features of a disease. Studies of these phenotype-driven animal models may identify genes that cause disease and may also provide a valuable resource for investigating pathogenesis. One strain of mice, B6-Lyst, has several key features of human XFS, including ocular production of exfoliation-like material, and stereotypical iris abnormalities. Studies of this range of mice and other public mouse genetic resources have provided some important insights into the biology of XFS and may be useful for future studies to test the efficacy of drug therapies.

Amino Acid Oxidoreductases - genetics

Animals

Exfoliation Syndrome - physiopathology

Glaucoma, Open-Angle - genetics

Humans

Glaucoma, Open-Angle - physiopathology

Mice, Transgenic

Mice

Exfoliation Syndrome - genetics

Disease Models, Animal

Mice, Knockout

Details

Title: Subtitle: Update on Animal Models of Exfoliation Syndrome
Creators: Michael G Anderson - University of Iowa, The University of Iowa Institute for Vision Research
Kacie J Meyer - University of Iowa
Adam Hedberg-Buenz - University of Iowa
John H Fingert - University of Iowa
Resource Type: Journal article
Publication Details: Journal of glaucoma, Vol.27 Suppl 1(7), pp.S78-S82
DOI: 10.1097/IJG.0000000000000911
PMID: 29419647
PMCID: PMC6028301
NLM abbreviation: J Glaucoma
ISSN: 1536-481X
eISSN: 1536-481X
Publisher: United States
Grant note: I01 RX001481 / RRD VA R01 EY023512 / NEI NIH HHS P30 EY025580 / NEI NIH HHS R01 EY017673 / NEI NIH HHS
Language: English
Date published: 07/2018
Academic Unit: Molecular Physiology and Biophysics; Ophthalmology and Visual Sciences
Record Identifier: 9983979952402771

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