Update on acute kidney injury in the neonate

Jennifer G Jetton; David J Askenazi

doi:10.1097/MOP.0b013e32834f62d5

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Journal article

Update on acute kidney injury in the neonate

Jennifer G Jetton and David J Askenazi

Current opinion in pediatrics, Vol.24(2), pp.191-281

04/2012

DOI: 10.1097/MOP.0b013e32834f62d5

PMCID: PMC5545784

PMID: 22227783

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https://www.ncbi.nlm.nih.gov/pmc/articles/5545784View

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Abstract

Acute kidney injury (AKI) is associated with increased risk of morbidity and mortality in critically ill children and adults. Neonates remain an understudied group, although previous evidence suggests that this association holds true for them as well. Attention to the issue of neonatal AKI is increasing. New studies in very low-birthweight infants, infants with congenital heart disease who undergo cardiopulmonary bypass, those who receive extracorporeal membrane oxygenation and infants with perinatal depression continue to demonstrate that AKI is common in neonates and associated with increased risk of morbidity and mortality. Additional advances in the field of neonatal AKI include adaptation of modern, categorical AKI definitions, as well as further evaluation of novel urinary biomarkers (e.g., neutrophil gelatinase-associated lipocalin) in this patient group. AKI is an independent risk factor for poor outcomes in critically ill neonates. Our ability to improve outcomes for these patients depends on heightened awareness of this issue both at the bedside as well as in research, commitment to using standardized AKI definitions in order to pool and compare data more effectively and improvement in our diagnostic methods with better AKI biomarkers so that we can identify AKI and intervene much earlier in the disease course.

Severity of Illness Index

Biomarkers - urine

Acute Kidney Injury - drug therapy

Infant, Very Low Birth Weight

Humans

Biomedical Research - trends

Extracorporeal Membrane Oxygenation - adverse effects

Incidence

Heart Defects, Congenital - complications

Acute Kidney Injury - diagnosis

Biomedical Research - methods

Acute Kidney Injury - epidemiology

Acute Kidney Injury - etiology

Infant, Newborn

Details

Title: Subtitle: Update on acute kidney injury in the neonate
Creators: Jennifer G Jetton - Division of Nephrology, Dialysis and Transplantation, University of Iowa Children's Hospital, Iowa City, Iowa, USA
David J Askenazi
Resource Type: Journal article
Publication Details: Current opinion in pediatrics, Vol.24(2), pp.191-281
DOI: 10.1097/MOP.0b013e32834f62d5
PMID: 22227783
PMCID: PMC5545784
NLM abbreviation: Curr Opin Pediatr
ISSN: 1040-8703
eISSN: 1531-698X
Grant note: P30 DK079337 / NIDDK NIH HHS
Language: English
Date published: 04/2012
Academic Unit: Stead Family Department of Pediatrics
Record Identifier: 9984093214502771

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221 Times Cited - Web of Science