Journal article
Update on biphasic anaphylaxis
Current opinion in allergy and clinical immunology, Vol.16(4), pp.346-351
08/01/2016
DOI: 10.1097/ACI.0000000000000279
PMID: 27253484
Abstract
Purpose of review
Biphasic anaphylaxis is a well documented complication of anaphylaxis, but it has been inconsistently defined in the literature. Analysis of contemporary studies of biphasic anaphylaxis based on modern definitions is needed.
Recent findings
The rate of biphasic reactions in contemporary literature ranges from 0.4 to 14.7% depending on the study population. Observational studies have reported risk factors associated with the development of biphasic reactions; however, findings have been inconsistent and of questionable generalizability. Although life-threatening biphasic reactions are rare, up to 50% of biphasic reactions will require treatment with epinephrine. Early epinephrine administration may have a role in prevention of biphasic reactions, but the role of steroids needs further investigation. The optimal duration of observation is yet to be determined.
Summary
Given the relative rarity of life-threatening biphasic anaphylaxis and the new context of the NIAID/FAAN standardized definition, further research regarding biphasic anaphylaxis is needed to better elucidate the care model for anaphylaxis patients with a focus on: prevention of biphasic reactions; identification of patients at increased risk of a biphasic reaction; determination of appropriate observation strategies for anaphylaxis patients; and patient education and preparation for management of potential biphasic reactions.
Details
- Title: Subtitle
- Update on biphasic anaphylaxis
- Creators
- Sangil Lee - Mayo Clinic Health SystemAnnie T. Sadosty - Mayo Clin, Dept Emergency Med, Rochester, MN USARonna L. Campbell - Mayo Clin, Dept Emergency Med, Rochester, MN USA
- Resource Type
- Journal article
- Publication Details
- Current opinion in allergy and clinical immunology, Vol.16(4), pp.346-351
- DOI
- 10.1097/ACI.0000000000000279
- PMID
- 27253484
- NLM abbreviation
- Curr Opin Allergy Clin Immunol
- ISSN
- 1528-4050
- eISSN
- 1473-6322
- Publisher
- Lippincott Williams & Wilkins
- Number of pages
- 6
- Language
- English
- Date published
- 08/01/2016
- Academic Unit
- Emergency Medicine; Injury Prevention Research Center
- Record Identifier
- 9984296985102771
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