Update on intra-arterial chemotherapy for retinoblastoma

Mario Zanaty; Guilherme Barros; Nohra Chalouhi; Robert M Starke; Philip Manasseh; Stavropoula I Tjoumakaris; Carol L Shields; David Hasan; Ketan Bulsara; Robert H Rosenwasser; Pascal Jabbour

doi:10.1155/2014/869604

Back

Update on intra-arterial chemotherapy for retinoblastoma

Journal article

Open access

Update on intra-arterial chemotherapy for retinoblastoma

Mario Zanaty, Guilherme Barros, Nohra Chalouhi, Robert M Starke, Philip Manasseh, Stavropoula I Tjoumakaris, Carol L Shields, David Hasan, Ketan Bulsara, Robert H Rosenwasser, …

TheScientificWorld, Vol.2014, pp.869604-6

2014

DOI: 10.1155/2014/869604

PMCID: PMC4227378

PMID: 25405236

Files and links (1)

url

https://doi.org/10.1155/2014/869604View

Published (Version of record) Open Access

Abstract

The tools for managing retinoblastoma have been increasing in the past decade. While globe-salvage still relies heavily on intravenous chemotherapy, tumors in advanced stage that failed chemotherapy are now referred for intra-arterial chemotherapy (IAC) to avoid enucleation. However, IAC still has many obstacles to overcome. We present an update on the indications, complications, limitations, success, and technical aspects of IAC. Given its safety and high efficacy, it is expected that IAC will replace conventional strategies and will become a first-line option even for tumors that are amenable for other strategies.

Infusions, Intra-Arterial - methods

Retinoblastoma - economics

Eye Enucleation - economics

Humans

Retinoblastoma - drug therapy

Retinal Neoplasms - pathology

Salvage Therapy

Treatment Outcome

Antineoplastic Agents - therapeutic use

Melphalan - therapeutic use

Retinoblastoma - pathology

Retinal Neoplasms - drug therapy

Retinal Neoplasms - economics

Ophthalmic Artery

Retinal Neoplasms - surgery

Eye Enucleation - methods

Child

Retinoblastoma - surgery

Details

Title: Subtitle: Update on intra-arterial chemotherapy for retinoblastoma
Creators: Mario Zanaty - Department of Neurosurgery, Thomas Jefferson University and Jefferson Hospital for Neuroscience, Philadelphia, PA 19107, USA
Guilherme Barros - Department of Neurosurgery, Thomas Jefferson University and Jefferson Hospital for Neuroscience, Philadelphia, PA 19107, USA
Nohra Chalouhi - Department of Neurosurgery, Thomas Jefferson University and Jefferson Hospital for Neuroscience, Philadelphia, PA 19107, USA
Robert M Starke - Department of Neurosurgery, University of Virginia, Charlottesville, VA 22908, USA
Philip Manasseh - Department of Neurosurgery, Thomas Jefferson University and Jefferson Hospital for Neuroscience, Philadelphia, PA 19107, USA
Stavropoula I Tjoumakaris - Department of Neurosurgery, Thomas Jefferson University and Jefferson Hospital for Neuroscience, Philadelphia, PA 19107, USA
Carol L Shields - Department of Ophthalmology, Thomas Jefferson University Hospital, Philadelphia, PA 19017, USA
David Hasan - Department of Neurosurgery, University of Iowa School of Medicine, Iowa City, IA 52242, USA
Ketan Bulsara - Department of Neurosurgery, Yale University School of Medicine, New Haven, CT 06510, USA
Robert H Rosenwasser - Department of Neurosurgery, Thomas Jefferson University and Jefferson Hospital for Neuroscience, Philadelphia, PA 19107, USA
Pascal Jabbour - Department of Neurosurgery, Thomas Jefferson University and Jefferson Hospital for Neuroscience, Philadelphia, PA 19107, USA ; Department of Neurological Surgery, Division of Neurovascular Surgery and Endovascular Neurosurgery, Thomas Jefferson University Hospital, 909 Walnut Street, 2nd Floor, Philadelphia, PA 19107, USA
Resource Type: Journal article
Publication Details: TheScientificWorld, Vol.2014, pp.869604-6
DOI: 10.1155/2014/869604
PMID: 25405236
PMCID: PMC4227378
NLM abbreviation: ScientificWorldJournal
ISSN: 2356-6140
eISSN: 1537-744X
Publisher: United States
Language: English
Date published: 2014
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Iowa Neuroscience Institute; Neurosurgery; Otolaryngology
Record Identifier: 9984040257402771

Metrics

37 Record Views