Journal article
Update on the genetics of nonbacterial osteomyelitis in humans
Current opinion in rheumatology, Vol.30(5), pp.521-525
09/2018
DOI: 10.1097/BOR.0000000000000530
PMID: 29912021
Abstract
To summarize the current advances in our understanding or the genetic basis of nonbacterial osteomyelitis.
Chronic recurrent multifocal osteomyelitis (CRMO) is a complex genetic disorder. Past discoveries identified several single gene defects (LPIN2, Pstpip2 and IL1RN) that cause IL-1-mediated sterile multifocal osteomyelitis. Recently Lorden et al.'s studies show that LIPIN2 deficiency can activate the NLRP3 inflammasome through alterations in the function of P2X7 receptor providing evidence that Majeed syndrome is an NLRP3 inflammasomopathy. New gene discoveries include the identification of FBLIM1 as a CRMO susceptibility gene. Mutations in FBLIM1 were found in a consanguineous family with CRMO. Fblim1 is one of the most significantly differentially expressed gene in bone from chronic multifocal osteomyelitis (cmo) mice, plays a role in IL-10-driven anti-inflammatory responses, and is involved in the physiology of bone remodeling. Lastly, new data on the putative CRMO susceptibility locus on chromosome 18 is presented here. Using Sanger sequencing, rather than microsatellite analysis, the DS18S60 susceptibility region could not be replicated in a larger cohort.
CRMO occurs in humans, nonhuman primates, dogs and mice. There is a genetic component to disease but the genetic basis has only been identified for a small percentage of all cases.
Details
- Title: Subtitle
- Update on the genetics of nonbacterial osteomyelitis in humans
- Creators
- Allison J Cox - Division of Pediatric Rheumatology, University of Iowa Carver College of Medicine, Iowa City, Iowa, USAPolly J Ferguson
- Resource Type
- Journal article
- Publication Details
- Current opinion in rheumatology, Vol.30(5), pp.521-525
- Publisher
- United States
- DOI
- 10.1097/BOR.0000000000000530
- PMID
- 29912021
- ISSN
- 1040-8711
- eISSN
- 1531-6963
- Grant note
- R01 AR059703 / NIAMS NIH HHS R01 NS098590 / NINDS NIH HHS
- Language
- English
- Date published
- 09/2018
- Academic Unit
- Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Rheumatology, Allergy, and Immunology
- Record Identifier
- 9984070506102771
Metrics
22 Record Views