Journal article
Updated Priorities for Cerebroprotection Trials
Stroke (1970), Vol.57(3), pp.829-836
03/2026
DOI: 10.1161/STROKEAHA.125.052147
PMID: 41263084
Abstract
A STAIR XIII workshop was held to discuss aspects of trials likely to have the greatest impact on detecting meaningful treatment effects of cerebroprotection in acute stroke. Intended goals for hyperacute protection should be focused on preserving penumbral tissue and delaying infarct core growth to augment the impact of reperfusion therapies. Infarct volume is a biologically and clinically meaningful surrogate imaging marker to assess the treatment effects of cerebroprotection. Lastly, clinical outcome measures for cerebroprotection should include domain-specific and patient-centered outcomes to detect clinically meaningful changes across multiple functional domains.
Details
- Title: Subtitle
- Updated Priorities for Cerebroprotection Trials
- Creators
- Sean I Savitz - The University of Texas Health Science Center at HoustonEdgar A Samaniego - University of IowaDavid S Liebeskind - University of California, Los AngelesJohannes Boltze - University of WarwickSTAIR XIII Participants
- Resource Type
- Journal article
- Publication Details
- Stroke (1970), Vol.57(3), pp.829-836
- DOI
- 10.1161/STROKEAHA.125.052147
- PMID
- 41263084
- NLM abbreviation
- Stroke
- ISSN
- 1524-4628
- eISSN
- 1524-4628
- Publisher
- American Heart Association
- Language
- English
- Electronic publication date
- 11/20/2025
- Date published
- 03/2026
- Academic Unit
- Neurology; Radiology; Iowa Neuroscience Institute; Neurosurgery
- Record Identifier
- 9985033872502771
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