Updating “Dataset of transcriptomic changes that occur in human preadipocytes over a 3-day course of exposure to 3,3’,4,4’,5-Pentachlorobiphenyl (PCB126)” with additional data on exposure to 2,2′,5,5′-tetrachorobiphenyl (PCB52) or its 4-hydroxy metabolite (4-OH-PCB52)

Francoise A. Gourronc; Michael S. Chimenti; Hans-Joachim Lehmler; James A. Ankrum; Aloysius J. Klingelhutz

doi:10.1016/j.dib.2023.109415

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Updating “Dataset of transcriptomic changes that occur in human preadipocytes over a 3-day course of exposure to 3,3’,4,4’,5-Pentachlorobiphenyl (PCB126)” with additional data on exposure to 2,2′,5,5′-tetrachorobiphenyl (PCB52) or its 4-hydroxy metabolite (4-OH-PCB52)

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Updating “Dataset of transcriptomic changes that occur in human preadipocytes over a 3-day course of exposure to 3,3’,4,4’,5-Pentachlorobiphenyl (PCB126)” with additional data on exposure to 2,2′,5,5′-tetrachorobiphenyl (PCB52) or its 4-hydroxy metabolite (4-OH-PCB52)

Francoise A. Gourronc, Michael S. Chimenti, Hans-Joachim Lehmler, James A. Ankrum and Aloysius J. Klingelhutz

Data in brief, Vol.49, 109415

08/2023

DOI: 10.1016/j.dib.2023.109415

PMCID: PMC10375549

PMID: 37520642

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Abstract

Polychlorinated biphenyls (PCBs) were used extensively in building materials, including those used in schools. PCBs accumulate in fat, and exposure to PCBs is associated with the development of cancer, neurodevelopmental disorders, cardiovascular disease, obesity, and diabetes. The non-dioxin-like PCB congener, PCB52 (2,2′,5,5′-tetrachorobiphenyl), is found at one of the highest levels of any congener in school air. PCB52 is oxidized in the liver to hydroxylated forms, mainly 4-OH-PCB52 (2,2’,5,5’-tetrachlorobiphenyl-4-ol). In a previous study, we reported on RNAseq data generated from exposure of human preadipocytes to the dioxin-like PCB congener, PCB126. In this new dataset, we used identical techniques to examine alterations in gene transcript levels in human preadipocytes exposed to PCB52 or 4-OH-PCB52 over a time course. This updated set of data provides a comprehensive transcriptional profile of changes that occur in preadipocytes exposed to PCB52 or 4-OH-PCB52 over time and allows for comparison of these changes between the parent compound and its hydroxy metabolite. The datasets will allow others to explore how PCB52 and 4-OH-PCB52 impact biological pathways in preadipocytes. Further studies can be performed to determine how these changes might lead to disease.

Diabetes

Obesity

Adipose

Metabolite

PCB52

Polychlorinated Biphenyls

Preadipocytes

RNAseq

Details

Title: Subtitle: Updating “Dataset of transcriptomic changes that occur in human preadipocytes over a 3-day course of exposure to 3,3’,4,4’,5-Pentachlorobiphenyl (PCB126)” with additional data on exposure to 2,2′,5,5′-tetrachorobiphenyl (PCB52) or its 4-hydroxy metabolite (4-OH-PCB52)
Creators: Francoise A. Gourronc - University of Iowa
Michael S. Chimenti - University of Iowa
Hans-Joachim Lehmler - University of Iowa
James A. Ankrum - University of Iowa
Aloysius J. Klingelhutz - University of Iowa
Resource Type: Journal article
Publication Details: Data in brief, Vol.49, 109415
DOI: 10.1016/j.dib.2023.109415
PMID: 37520642
PMCID: PMC10375549
NLM abbreviation: Data Brief
ISSN: 2352-3409
eISSN: 2352-3409
Publisher: Elsevier Inc
Language: English
Electronic publication date: 07/2023
Date published: 08/2023
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Microbiology and Immunology; Occupational and Environmental Health; Iowa Neuroscience Institute; Radiation Oncology; Fraternal Order of Eagles Diabetes Research Center; Iowa Superfund Research Program; Iowa Institute of Human Genetics
Record Identifier: 9984445625402771

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