Upper Eyelid Response to Topical 0.5% Apraclonidine

Christopher A Kirkpatrick; Erin M Shriver; Thomas J E Clark; Randy H Kardon

doi:10.1097/IOP.0000000000000843

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Upper Eyelid Response to Topical 0.5% Apraclonidine

Journal article

Peer reviewed

Upper Eyelid Response to Topical 0.5% Apraclonidine

Christopher A Kirkpatrick, Erin M Shriver, Thomas J E Clark and Randy H Kardon

Ophthalmic plastic and reconstructive surgery, Vol.34(1), pp.13-19

01/2018

DOI: 10.1097/IOP.0000000000000843

PMID: 27984360

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Abstract

To describe the change in upper eyelid position in a self-reportedly normal population after the administration of topical 0.5% apraclonidine in each eye. One hundred self-reportedly normal subjects received a 1-time administration of topical 0.5% apraclonidine in each eye. Digital photographs were taken at baseline and then 30 and 45 minutes following apraclonidine instillation. Marginal reflex distance 1 was determined via image analysis of acquired digital photographs (image-derived measurements are given the prefix "i" in this study). The horizontal corneal diameter was used as a constant measurement scale in each photograph. The mean increase in i-marginal reflex distance 1 post-administration of 0.5% apraclonidine was +0.70 ± 0.60 mm (range, -0.94 to +2.66 mm) after 30 minutes and +0.68 ± 0.59 mm (range, -0.69 to +2.54 mm) after 45 minutes. Of the 200 total eyelids in 100 subjects, 181 (90.5%) had an increase in i-marginal reflex distance 1 at 30 minutes. Of the 100 subjects, 85 (85%) had a bilateral increase in i-marginal reflex distance 1, 4 (4%) had a bilateral decrease, and 11 (11%) had a unilateral increase with a contralateral decrease. Given its predominant small-amplitude upper eyelid elevating effect, topical apraclonidine may be a useful off-label alternative treatment for mild upper eyelid ptosis and in eyelid asymmetry due to eyelid retraction through use in the contralateral eye.

Eyelids - physiology

Follow-Up Studies

Humans

Middle Aged

Self Report

Eyelids - drug effects

Male

Healthy Volunteers

Blepharoptosis - drug therapy

Blepharoptosis - diagnostic imaging

Dose-Response Relationship, Drug

Photography

Young Adult

Clonidine - analogs & derivatives

Adrenergic alpha-2 Receptor Agonists - administration & dosage

Aged, 80 and over

Ophthalmic Solutions

Adult

Female

Aged

Clonidine - administration & dosage

Administration, Topical

Eyelids - diagnostic imaging

Details

Title: Subtitle: Upper Eyelid Response to Topical 0.5% Apraclonidine
Creators: Christopher A Kirkpatrick - Department of Ophthalmology and Visual Sciences, University of Iowa Hospital and Clinics, and Veteran's Affairs Center for the Prevention and Treatment of Visual Loss, Iowa City, Iowa, U.S.A
Erin M Shriver - Department of Ophthalmology and Visual Sciences, University of Iowa Hospital and Clinics, and Veteran's Affairs Center for the Prevention and Treatment of Visual Loss, Iowa City, Iowa, U.S.A
Thomas J E Clark - Department of Ophthalmology and Visual Sciences, University of Iowa Hospital and Clinics, and Veteran's Affairs Center for the Prevention and Treatment of Visual Loss, Iowa City, Iowa, U.S.A
Randy H Kardon
Resource Type: Journal article
Publication Details: Ophthalmic plastic and reconstructive surgery, Vol.34(1), pp.13-19
DOI: 10.1097/IOP.0000000000000843
PMID: 27984360
NLM abbreviation: Ophthalmic Plast Reconstr Surg
ISSN: 0740-9303
eISSN: 1537-2677
Publisher: United States
Language: English
Date published: 01/2018
Academic Unit: Iowa Neuroscience Institute; Otolaryngology; Ophthalmology and Visual Sciences
Record Identifier: 9983979967502771

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