Journal article
Upper Limit of Vitamin E in Infant Formulas
The Journal of nutrition, Vol.119(suppl_12), pp.1829-1831
12/01/1989
DOI: 10.1093/jn/119.12_Suppl.1829
PMID: 2693643
Abstract
Reports of toxicity to enterally administered vitamin E are rare in infants. However, increased risks of sepsis and necrotizing enterocolitis have been reported after both enteral and parenteral vitamin E, primarily when plasma (or serum) vitamin E levels exceed 3.5 mg/dl. Levels this high are seldom seen with enteral vitamin E when intake is 25 mg d-alpha-tocopherol equivalent/(kg.d) or less. Intakes below this threshold will be provided by infant formulas with vitamin E to energy ratios of up to 20 mg/100 kcal (30 IU/100 kcal) so long as energy intake does not exceed 125 kcal/(kg.d). To allow a margin of safety, it would be reasonable to limit the amount of vitamin E added to the formula during its manufacture to half this amount, or 10 mg/100 kcal (15 IU/100 kcal). This level coincides with the highest levels of vitamin E found in human colostrum and is 20 times the recommended lower limit for vitamin E in infant formula of 0.5 mg/100 kcal.
Details
- Title: Subtitle
- Upper Limit of Vitamin E in Infant Formulas
- Creators
- Edward F Bell
- Resource Type
- Journal article
- Publication Details
- The Journal of nutrition, Vol.119(suppl_12), pp.1829-1831
- DOI
- 10.1093/jn/119.12_Suppl.1829
- PMID
- 2693643
- ISSN
- 0022-3166
- eISSN
- 1541-6100
- Language
- English
- Date published
- 12/01/1989
- Academic Unit
- Stead Family Department of Pediatrics; Neonatology
- Record Identifier
- 9984093333002771
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