Upper aerodigestive tract cancer in patients with chronic lymphocytic leukemia: incidence, stage, and outcome

Nitin A Pagedar; Thorvardur R Halfdanarson; Lucy H Karnell; Henry T Hoffman; Gerry F Funk

doi:10.1001/jamaoto.2013.723

Back

Upper aerodigestive tract cancer in patients with chronic lymphocytic leukemia: incidence, stage, and outcome

Journal article

Open access

Peer reviewed

Upper aerodigestive tract cancer in patients with chronic lymphocytic leukemia: incidence, stage, and outcome

Nitin A Pagedar, Thorvardur R Halfdanarson, Lucy H Karnell, Henry T Hoffman and Gerry F Funk

Archives of otolaryngology--head & neck surgery, Vol.138(12), pp.1171-1175

12/2012

DOI: 10.1001/jamaoto.2013.723

PMID: 23247237

Files and links (1)

url

https://doi.org/10.1001/jamaoto.2013.723View

Published (Version of record) Open Access

Abstract

To compare incidence, stage, and survival of upper aerodigestive tract (UADT) cancers in patients with and without chronic lymphocytic leukemia (CLL). Inception cohort. National database. Individuals with CLL and UADT cancers included in the Surveillance, Epidemiology, and End Results (SEER) database. Incidence was compared by computing standardized incidence ratio (SIR), the ratio of observed UADT cancers in patients with CLL, and the number of UADT cancers expected based on the characteristics of patients with CLL and population incidence of UADT cancers. The association between CLL and UADT cancer stage was measured using odds ratio (OR) calculations. Survival of patients with UADT cancer with and without CLL was compared. For the SIR calculation, 36 985 patients with CLL contributed a mean 6.36 years of follow-up each, for a total of 235 314 person-years of follow-up. The SIR was 1.18 (95% CI, 0.97-1.41) for UADT cancers; 1.52 (95% CI, 1.18-1.93) for laryngeal cancer; and 1.92 (95% CI, 1.05-3.23) for cancers of the nasal cavity and paranasal sinuses. In the stage and survival analyses, 253 patients with CLL followed by a UADT cancer were compared with 133 840 patients with 1 UADT cancer only. Cancers of the UADT in patients with CLL were more likely localized (OR, 0.50; 95% CI, 0.37-0.68). Relative survival was worse in patients with CLL. In multivariate analysis, CLL was independently associated with poorer observed survival (hazard ratio, 1.45; 95% CI, 1.24-1.70). Larynx and nasal cavity cancers were more common in patients with CLL. Overall incidence of UADT cancers was not significantly elevated. Cancers of the UADT in patients with CLL were more likely to be localized at diagnosis than those in patients without CLL. Finally, CLL was associated with poorer survival outcomes.

Otorhinolaryngologic Neoplasms - therapy

United States - epidemiology

SEER Program

Humans

Middle Aged

Otorhinolaryngologic Neoplasms - pathology

Male

Survival Rate

Treatment Outcome

Leukemia, Lymphocytic, Chronic, B-Cell - epidemiology

Leukemia, Lymphocytic, Chronic, B-Cell - pathology

Incidence

Leukemia, Lymphocytic, Chronic, B-Cell - therapy

Otorhinolaryngologic Neoplasms - epidemiology

Female

Registries

Aged

Neoplasm Staging

Details

Title: Subtitle: Upper aerodigestive tract cancer in patients with chronic lymphocytic leukemia: incidence, stage, and outcome
Creators: Nitin A Pagedar
Thorvardur R Halfdanarson
Lucy H Karnell
Henry T Hoffman
Gerry F Funk
Resource Type: Journal article
Publication Details: Archives of otolaryngology--head & neck surgery, Vol.138(12), pp.1171-1175
DOI: 10.1001/jamaoto.2013.723
PMID: 23247237
NLM abbreviation: Arch Otolaryngol Head Neck Surg
ISSN: 0886-4470
eISSN: 1538-361X
Publisher: American Medical Association; United States
Language: English
Date published: 12/2012
Academic Unit: Radiation Oncology; Otolaryngology
Record Identifier: 9984006341302771

Metrics

20 Record Views

3 Times Cited - Web of Science