Uptake and predictors of colonoscopy use in family members not participating in cascade genetic testing for Lynch syndrome

Donald W Hadley; Dina Eliezer; Yonit Addissie; Andrea Goergen; Sato Ashida; Laura Koehly

doi:10.1038/s41598-020-72938-z

Back

Uptake and predictors of colonoscopy use in family members not participating in cascade genetic testing for Lynch syndrome

Journal article

Open access

Peer reviewed

Uptake and predictors of colonoscopy use in family members not participating in cascade genetic testing for Lynch syndrome

Donald W Hadley, Dina Eliezer, Yonit Addissie, Andrea Goergen, Sato Ashida and Laura Koehly

Scientific reports, Vol.10(1), pp.15959-15959

09/29/2020

DOI: 10.1038/s41598-020-72938-z

PMCID: PMC7525436

PMID: 32994442

Files and links (1)

url

https://doi.org/10.1038/s41598-020-72938-zView

Published (Version of record) Open Access

Abstract

Cascade genetic testing provides a method to appropriately focus colonoscopy use in families with Lynch syndrome (LS). However, research suggests that up to two-thirds at risk to inherit LS don't participate. Within the United States, no studies have assessed colonoscopy use within this elusive and high-risk subset. We set forth to (1) document colonoscopy use within those not undergoing genetic testing (NGT) and (2) identify factors associated with completing colonoscopy. Data came from a cross sectional survey of families with molecularly confirmed LS. One hundred seventy-six (176) adults participated; 47 of unknown variant status and 129 with variant status known (59 carriers/70 non-carriers). Despite a high level of awareness of LS (85%) and identical recommendations for colonoscopy, NGT reported significantly lower use of colonoscopy than carriers (47% vs. 73%; p = 0.003). Our results show that perceived risk to develop colon cancer (AOR = 1.99, p < 0.05) and physician recommendations (AOR = 7.64, p < 0.01) are significant predictors of colonoscopy use across all family members controlling for carrier status. Given these findings, health care providers, should assess patients' perceived risk to develop cancer, assist them in adjusting risk perceptions and discuss recommendations for colonoscopy with all members in families with LS.Trial Registration Clinical Trials.gov Identifier: NCT00004210.

Adult

Colonic Neoplasms - genetics

Colonoscopy - trends

Colorectal Neoplasms, Hereditary Nonpolyposis - diagnosis

Colorectal Neoplasms, Hereditary Nonpolyposis - genetics

Cross-Sectional Studies

Family

Female

Genetic Predisposition to Disease - genetics

Genetic Testing - trends

Health Knowledge, Attitudes, Practice

Heterozygote

Humans

Male

Middle Aged

Mutation - genetics

Risk Factors

United States

Details

Title: Subtitle: Uptake and predictors of colonoscopy use in family members not participating in cascade genetic testing for Lynch syndrome
Creators: Donald W Hadley - Office of the Clinical Director, National Human Genome Research Institute, National Institutes of Health, 35 Convent Drive, MSC 3717, Bldg. 35, Room 1B205, Bethesda, MD, 20892-3717, USA. dhadley@mail.nih.gov
Dina Eliezer - Social Networks Methods Section, Social and Behavioral Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA
Yonit Addissie - Social Networks Methods Section, Social and Behavioral Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA
Andrea Goergen - Social Networks Methods Section, Social and Behavioral Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA
Sato Ashida - Department of Community and Behavioral Health, College of Public Health, University of Iowa, Iowa City, IA, USA
Laura Koehly - Social Networks Methods Section, Social and Behavioral Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA
Resource Type: Journal article
Publication Details: Scientific reports, Vol.10(1), pp.15959-15959
DOI: 10.1038/s41598-020-72938-z
PMID: 32994442
PMCID: PMC7525436
NLM abbreviation: Sci Rep
ISSN: 2045-2322
eISSN: 2045-2322
Language: English
Date published: 09/29/2020
Academic Unit: Injury Prevention Research Center; Public Policy Center (Archive); Community and Behavioral Health
Record Identifier: 9984214689102771

Metrics

5 Record Views

4 Times Cited - Web of Science