Uptake and retention of manganese contrast agents for PET and MRI in the rodent brain

Christina L Brunnquell; Reinier Hernandez; Stephen A Graves; Ivy Smit-Oistad; Robert J Nickles; Weibo Cai; M Elizabeth Meyerand; Masatoshi Suzuki

doi:10.1002/cmmi.1701

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Uptake and retention of manganese contrast agents for PET and MRI in the rodent brain

Journal article

Open access

Peer reviewed

Uptake and retention of manganese contrast agents for PET and MRI in the rodent brain

Christina L Brunnquell, Reinier Hernandez, Stephen A Graves, Ivy Smit-Oistad, Robert J Nickles, Weibo Cai, M Elizabeth Meyerand and Masatoshi Suzuki

Contrast media and molecular imaging, Vol.11(5), pp.371-380

09/2016

DOI: 10.1002/cmmi.1701

PMCID: PMC5140672

PMID: 27396476

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Abstract

Manganese-enhanced magnetic resonance imaging (MRI) is an established neuroimaging method for signal enhancement, tract tracing, and functional studies in rodents. Along with the increasing availability of combined positron emission tomography (PET) and MRI scanners, the recent development of the positron-emitting isotope Mn has prompted interest in the use of Mn as a dual-modality contrast agent. In this work, we characterized and compared the uptake of systemically delivered Mn and radioactive Mn in the rat brain for MRI and PET, respectively. Additionally, we examined the biodistribution of two formulations of Mn in the rat. In MRI, maximum uptake was observed one day following delivery of the highest MnCl dose tested (60 mg/kg), with some brain regions showing delayed maximum enhancement 2-4 days following delivery. In PET, we observed low brain uptake after systemic delivery, with a maximum of approximately 0.2% ID/g. We also studied the effect of final formulation vehicle (saline compared with MnCl ) on Mn organ biodistribution and brain uptake. We observed that the addition of bulk Mn carrier to Mn in solution resulted in significantly reduced Mn uptake in the majority of organs, including the brain. These results lay the groundwork for further development of Mn PET or dual Mn-enhanced PET-MR neuroimaging in rodents, and indicate several interesting potential applications of Mn PET in other organs and systems. Copyright © 2016 John Wiley & Sons, Ltd.

Animals

Brain - diagnostic imaging

Brain - metabolism

Chlorides

Contrast Media - chemistry

Contrast Media - pharmacokinetics

Magnetic Resonance Imaging - methods

Manganese - chemistry

Manganese - pharmacokinetics

Manganese Compounds

Multimodal Imaging - methods

Neuroimaging - methods

Positron-Emission Tomography - methods

Radioisotopes - chemistry

Radioisotopes - pharmacokinetics

Rats

Tissue Distribution

Details

Title: Subtitle: Uptake and retention of manganese contrast agents for PET and MRI in the rodent brain
Creators: Christina L Brunnquell - University of Wisconsin–Madison
Reinier Hernandez - University of Wisconsin–Madison
Stephen A Graves - University of Wisconsin–Madison
Ivy Smit-Oistad - University of Wisconsin–Madison
Robert J Nickles - University of Wisconsin–Madison
Weibo Cai - University of Wisconsin–Madison
M Elizabeth Meyerand - University of Wisconsin–Madison
Masatoshi Suzuki - University of Wisconsin–Madison
Resource Type: Journal article
Publication Details: Contrast media and molecular imaging, Vol.11(5), pp.371-380
DOI: 10.1002/cmmi.1701
PMID: 27396476
PMCID: PMC5140672
NLM abbreviation: Contrast Media Mol Imaging
ISSN: 1555-4309
eISSN: 1555-4317
Grant note: T32 GM008349 / NIGMS NIH HHS UL1 TR000427 / NCATS NIH HHS T32 CA009206 / NCI NIH HHS R01 NS091540 / NINDS NIH HHS
Language: English
Date published: 09/2016
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Radiology; Radiation Oncology
Record Identifier: 9984383896602771

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