Urban Particulate Matter Impairment of Airway Surface Liquid-Mediated Coronavirus Inactivation

Emma M Stapleton; Jennifer L Welch; Erika A Ubeda; Jinhua Xiang; Joseph Zabner; Ian M Thornell; Matthew W Nonnenmann; Jack T Stapleton; Alejandro P Comellas

doi:10.1093/infdis/jiab545

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Urban Particulate Matter Impairment of Airway Surface Liquid-Mediated Coronavirus Inactivation

Journal article

Open access

Peer reviewed

Urban Particulate Matter Impairment of Airway Surface Liquid-Mediated Coronavirus Inactivation

Emma M Stapleton, Jennifer L Welch, Erika A Ubeda, Jinhua Xiang, Joseph Zabner, Ian M Thornell, Matthew W Nonnenmann, Jack T Stapleton and Alejandro P Comellas

The Journal of infectious diseases, Vol.225(2), pp.214-218

01/18/2022

DOI: 10.1093/infdis/jiab545

PMCID: PMC8689861

PMID: 34734257

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https://doi.org/10.1093/infdis/jiab545View

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Abstract

Air pollution particulate matter (PM) is associated with SARS-CoV-2 infection and severity, although mechanistic studies are lacking. We tested whether airway surface liquid (ASL) from primary human airway epithelial cells is antiviral against SARS-CoV-2 and human alphacoronavirus 229E (CoV-229E) (responsible for common colds), and whether PM (urban, indoor air pollution [IAP], volcanic ash) affected ASL antiviral activity. ASL inactivated SARS-CoV-2 and CoV-229E. Independently, urban PM also decreased SARS-CoV-2 and CoV-229E infection, and IAP PM decreased CoV-229E infection. However, in combination, urban PM impaired ASL's antiviral activity against both viruses, and the same effect occurred for IAP PM and ash against SARS-CoV-2, suggesting that PM may enhance SARS-CoV-2 infection.

Polymerase Chain Reaction

Urban Health

Antiviral Agents - pharmacology

Coronavirus 229E, Human

COVID-19 - prevention & control

COVID-19 - transmission

Humans

Immunity, Innate

Particulate Matter - adverse effects

SARS-CoV-2

Urban Population

Details

Title: Subtitle: Urban Particulate Matter Impairment of Airway Surface Liquid-Mediated Coronavirus Inactivation
Creators: Emma M Stapleton - University of Iowa
Jennifer L Welch - Iowa City VA Health Care System
Erika A Ubeda - University of Iowa
Jinhua Xiang - Iowa City VA Health Care System
Joseph Zabner - University of Iowa
Ian M Thornell - University of Iowa
Matthew W Nonnenmann - University of Iowa
Jack T Stapleton - Iowa City VA Health Care System
Alejandro P Comellas - University of Iowa
Resource Type: Journal article
Publication Details: The Journal of infectious diseases, Vol.225(2), pp.214-218
DOI: 10.1093/infdis/jiab545
PMID: 34734257
PMCID: PMC8689861
ISSN: 0022-1899
eISSN: 1537-6613
Grant note: HL091842-11 / NIH HHS P30 ES005605 / NIEHS NIH HHS Origins of Cystic Fibrosis Airway Disease P01 HL091842 / NHLBI NIH HHS U54 TR001356 / NCATS NIH HHS I01 BX000207 / BLRD VA BX000207 / VA
Language: English
Date published: 01/18/2022
Academic Unit: Pulmonary, Critical Care, and Occupational Medicine; Microbiology and Immunology; Occupational and Environmental Health; Infectious Diseases; ICTS; Internal Medicine
Record Identifier: 9984226819602771

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