Journal article
Uric acid as a mediator of diabetic nephropathy
Seminars in nephrology, Vol.31(5), pp.459-465
09/2011
DOI: 10.1016/j.semnephrol.2011.08.011
PMCID: PMC3197214
PMID: 22000654
Abstract
Despite advances in the management of patients with diabetes, diabetic nephropathy (DN) remains the most common cause of end-stage renal disease in the United States and worldwide. Inflammation and endothelial dysfunction appear to play a central role in the onset and the progression of DN. Recent evidence has emerged in the past decade to suggest uric acid is an inflammatory factor and may play a role in endothelial dysfunction. This has lead our group and others to explore the role of uric acid in the onset and progression of DN. In this review, we highlight some of the animal and human studies that implicate uric acid in DN. Based on the evidence we review, we conclude the need for properly planned randomized controlled studies to decrease uric acid levels and assess the impact of such therapy on diabetic kidney disease.
Details
- Title: Subtitle
- Uric acid as a mediator of diabetic nephropathy
- Creators
- Diana I Jalal - Division of Renal Diseases and Hypertension, University of Colorado Denver, Aurora, CO 80045, USA. Diana.Jalal@ucdenver.eduDavid M MaahsPeter HovindTakahiko Nakagawa
- Resource Type
- Journal article
- Publication Details
- Seminars in nephrology, Vol.31(5), pp.459-465
- DOI
- 10.1016/j.semnephrol.2011.08.011
- PMID
- 22000654
- PMCID
- PMC3197214
- NLM abbreviation
- Semin Nephrol
- ISSN
- 0270-9295
- eISSN
- 1558-4488
- Grant note
- K23 DK075360 / NIDDK NIH HHS K23 DK075360-04 / NIDDK NIH HHS K23 DK088833 / NIDDK NIH HHS K23DK075630 / NIDDK NIH HHS HL-68607 / NHLBI NIH HHS K23 DK088833-01 / NIDDK NIH HHS 1K23DK088833 / NIDDK NIH HHS R01 HL068607 / NHLBI NIH HHS
- Language
- English
- Date published
- 09/2011
- Academic Unit
- Nephrology; Internal Medicine
- Record Identifier
- 9984094726102771
Metrics
28 Record Views