Journal article
Urinary Bisphenols and Obesity Prevalence Among U.S. Children and Adolescents
Journal of the Endocrine Society, Vol.3(9), pp.1715-1726
09/01/2019
DOI: 10.1210/js.2019-00201
PMCID: PMC6735733
PMID: 31528831
Abstract
Bisphenol A (BPA) has been recognized as an endocrine disrupting chemical and identified as an obesogen. Although once ubiquitous, human exposure to BPA has been declining owing to its substitution with other bisphenols. Two structurally similar substitutes, bisphenol S (BPS) and bisphenol F (BPF), have raised similar concerns, although fewer studies have been conducted on these newer derivatives. We used data from the US National Health and Nutrition Examination Surveys from 2013 to 2016 to evaluate associations between BPA, BPS, and BPF and body mass outcomes among children and adolescents aged 6 to 19 years. Concentrations of BPA, BPS, and BPF were measured in spot urine samples using HPLC with tandem mass spectrometry. General obesity was defined as >= 95th percentile of the age- and sex-standardized body mass index (BMI) z-scores according to the 2000 US norms. Abdominal obesity was defined as a waist circumference/height ratio of >= 0.5. BPA, BPS, and BPF were detected in 97.5%, 87.8%, and 55.2% of urine samples, respectively. Log-transformed urinary BPS concentrations were associated with an increased prevalence of general obesity (OR, 1.16; 95% CI, 1.02 to 1.32) and abdominal obesity (OR, 1.13; 95% CI, 1.02 to 1.27). BPF detection (vs not detected) was associated with an increased prevalence of abdominal obesity (OR, 1.29; 95% CI, 1.01 to 1.64) and continuous BMI z-score (beta = 0.10; 95% CI, 0.01 to 0.20). BPA and total bisphenols were not statistically significantly associated with general obesity, abdominal obesity, or any body mass outcome. These results suggest that BPA substitute chemicals are correlated with obesity in contemporary children. Copyright (C) 2019 Endocrine Society
Details
- Title: Subtitle
- Urinary Bisphenols and Obesity Prevalence Among U.S. Children and Adolescents
- Creators
- Melanie H. Jacobson - NYU Langone HealthMiriam Woodward - NYU Langone HealthWei Bao - University of IowaBuyun Liu - University of IowaLeonardo Trasande - NYU Langone Health
- Resource Type
- Journal article
- Publication Details
- Journal of the Endocrine Society, Vol.3(9), pp.1715-1726
- Publisher
- Endocrine Soc
- DOI
- 10.1210/js.2019-00201
- PMID
- 31528831
- PMCID
- PMC6735733
- ISSN
- 2472-1972
- eISSN
- 2472-1972
- Number of pages
- 12
- Grant note
- R01ES022972; R01ES029779; P30 ES000260; P30 ES005605 / National Institutes of Environmental Health Sciences; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS) R01ES029779 / NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS)
- Language
- English
- Date published
- 09/01/2019
- Academic Unit
- Epidemiology
- Record Identifier
- 9984363568302771
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