Journal article
Urinary Phthalate Biomarkers and Bone Mineral Density in Postmenopausal Women
The journal of clinical endocrinology and metabolism, Vol.106(7), pp.E2567-E2579
07/01/2021
DOI: 10.1210/clinem/dgab189
PMCID: PMC8266434
PMID: 33754148
Abstract
Context: Phthalates are endocrine-disrupting chemicals that could disrupt normal physiologic function, triggering detrimental impacts on bone.
Objective: We evaluated associations between urinary phthalate biomarkers and BMD in postmenopausal women participating in the prospective Women's Health Initiative (WHI).
Methods: We included WHI participants enrolled in the BMD substudy and selected for a nested case-control study of phthalates and breast cancer (N=1255). We measured 13 phthalate biomarkers and creatinine in 2 to 3 urine samples per participant collected over 3 years, when all participants were cancer free. Total hip and femoral neck BMD were measured at baseline and year 3, concurrent with urine collection, via dual-energy x-ray absorptiometry. We fit multivariable generalized estimating equation models and linear mixed-effects models to estimate cross-sectional and longitudinal associations, respectively, with stratification on postmenopausal hormone therapy (HT) use.
Results: In cross-sectional analyses, mono-3-carboxypropyl phthalate and the sum of di-isobutyl phthalate metabolites were inversely associated with total hip BMD among HT nonusers, but not among HT users. Longitudinal analyses showed greater declines in total hip BMD among HT nonusers and with highest concentrations of mono-3-carboxyoctyl phthalate (-1.80%; 95% CI, -2.81% to -0.78%) or monocarboxynonyl phthalate (-1.84%; 95% CI, -2.80% to -0.89%); similar associations were observed with femoral neck BMD. Among HT users, phthalate biomarkers were not associated with total hip or femoral neck BMD change.
Conclusion: Certain phthalate biomarkers are associated with greater percentage decreases in total hip and femoral neck BMD. These findings suggest that phthalate exposure may have clinically important effects on BMD, and potentially fracture risk.
Details
- Title: Subtitle
- Urinary Phthalate Biomarkers and Bone Mineral Density in Postmenopausal Women
- Creators
- Katherine W. Reeves - University of Massachusetts AmherstGabriela Vieyra - University of Massachusetts AmherstNydjie P. Grimes - University of Massachusetts AmherstJaymie Meliker - Stony Brook UniversityRebecca D. Jackson - The Ohio State UniversityJean Wactawski-Wende - University at Buffalo, State University of New YorkRobert Wallace - University of IowaR. Thomas Zoeller - University of Massachusetts AmherstCarol Bigelow - University of Massachusetts AmherstSusan E. Hankinson - University of Massachusetts AmherstJoAnn E. Manson - Brigham and Women's HospitalJane A. Cauley - University of PittsburghAntonia M. Calafat - Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA.
- Resource Type
- Journal article
- Publication Details
- The journal of clinical endocrinology and metabolism, Vol.106(7), pp.E2567-E2579
- DOI
- 10.1210/clinem/dgab189
- PMID
- 33754148
- PMCID
- PMC8266434
- NLM abbreviation
- J Clin Endocrinol Metab
- ISSN
- 0021-972X
- eISSN
- 1945-7197
- Publisher
- Endocrine Soc
- Number of pages
- 13
- Grant note
- National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA National Heart, Lung, and Blood Institute; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) R01ES024731; R01ES024731S1 / National Institute of Environmental Health Sciences; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS) HHSN268201600018C; HHSN268201600001C; HHSN268201600002C; HHSN268201600003C; HHSN268201600004C / US Department of Health and Human Services
- Language
- English
- Date published
- 07/01/2021
- Academic Unit
- Epidemiology; Injury Prevention Research Center; Internal Medicine
- Record Identifier
- 9984364402902771
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