Journal article
Urinary cGMP as biological marker of the renal activity of atrial natriuretic factor
American journal of physiology. Renal physiology, Vol.255(6), pp.F1220-F1224
12/01/1988
DOI: 10.1152/ajprenal.1988.255.6.F1220
PMID: 2849318
Abstract
Current evidence suggests guanosine 3',5'-cyclic monophosphate (cGMP) serves as the second messenger for atrial natriuretic factor (ANF) in the kidney in vivo. We examined whether extracellular cGMP accumulation quantitatively reflected the concentration of cGMP within renal cells and whether urinary excretion of cGMP correlated with the physiological action of ANF. cGMP egression was examined in renal epithelial LLC-PK1 cells. ANF augmented intracellular cGMP concentration and extracellular cGMP appearance. Extracellular cGMP was an excellent function of the time-integrated intracellular cGMP concentration. In clearance studies in awake rats, urinary cGMP was primarily of renal cellular origin and correlated with the natriuresis induced by ANF in a time-dependent and concentration-dependent fashion. Urinary cGMP excretion may be useful as a biological marker for the renal activity of ANF in vivo.
Details
- Title: Subtitle
- Urinary cGMP as biological marker of the renal activity of atrial natriuretic factor
- Creators
- K. R. Wong - University of California, San FranciscoM. H. Xie - University of California, San FranciscoL. B. Shi - University of California, San FranciscoF. Y. Liu - University of California, San FranciscoC. L. Huang - University of California, San FranciscoD. G. Gardner - University of California, San FranciscoM. G. Cogan - University of California, San Francisco
- Resource Type
- Journal article
- Publication Details
- American journal of physiology. Renal physiology, Vol.255(6), pp.F1220-F1224
- DOI
- 10.1152/ajprenal.1988.255.6.F1220
- PMID
- 2849318
- ISSN
- 1931-857X
- eISSN
- 1522-1466
- Language
- English
- Date published
- 12/01/1988
- Academic Unit
- Nephrology; Internal Medicine
- Record Identifier
- 9984360057402771
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