Urothelial antigen-specific CD4+ T cells function as direct effector cells and induce bladder autoimmune inflammation independent of CD8+ T cells

Wujiang Liu; Xiaohong Chen; David P. Evanoff; Yi Luo

doi:10.1038/mi.2010.90

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Urothelial antigen-specific CD4+ T cells function as direct effector cells and induce bladder autoimmune inflammation independent of CD8+ T cells

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Urothelial antigen-specific CD4+ T cells function as direct effector cells and induce bladder autoimmune inflammation independent of CD8+ T cells

Wujiang Liu, Xiaohong Chen, David P. Evanoff and Yi Luo

Mucosal immunology, Vol.4(4), pp.428-437

01/26/2011

DOI: 10.1038/mi.2010.90

PMCID: PMC3118865

PMID: 21270773

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Abstract

The role of CD4 + T cells in bladder autoimmune inflammation has not been identified due to the lack of a proper animal model. We investigated CD4 + T cell responses to bladder urothelial ovalbumin (OVA), a model self-antigen (Ag), in transgenic URO-OVA mice. The expression of bladder urothelial OVA rendered mice unresponsive to OVA and resulted in quick clearance of Ag-specific CD4 + T cells. Adoptive transfer of naïve OVA-specific CD4 + T cells led to exogenous T cell proliferation, activation, and bladder infiltration but no inflammatory induction. In contrast, adoptive transfer of pre-activated OVA-specific CD4 + T cells induced bladder inflammation. Studies further demonstrated that CD4 + T cells induced bladder inflammation in URO-OVA mice depleted of CD8 + T cells or deficient in the recombinase activating gene-1 (Rag-1 −/− ). These results indicate that urothelial Ag-specific CD4 + T cells can function as direct effector cells to induce bladder autoimmune inflammation independent of CD8 + T cells.

Autoimmunity

Bladder

Inflammation

T cells

Urothelium

Details

Title: Subtitle: Urothelial antigen-specific CD4+ T cells function as direct effector cells and induce bladder autoimmune inflammation independent of CD8+ T cells
Creators: Wujiang Liu - Roy J. and Lucille A. Carver College of Medicine
Xiaohong Chen - Roy J. and Lucille A. Carver College of Medicine
David P. Evanoff - Roy J. and Lucille A. Carver College of Medicine
Yi Luo - Roy J. and Lucille A. Carver College of Medicine
Resource Type: Journal article
Publication Details: Mucosal immunology, Vol.4(4), pp.428-437
DOI: 10.1038/mi.2010.90
PMID: 21270773
PMCID: PMC3118865
ISSN: 1933-0219
eISSN: 1935-3456
Language: English
Date published: 01/26/2011
Academic Unit: Urology
Record Identifier: 9984320060502771

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