Use of 99mTc-doxorubicin scintigraphy in females with breast cancer: A pilot study

F. I. Araujo; F. P.P. Proenca; C. G. Ferreira; S. C. Ventilari; P. H. Rosado De Castro; R. D. Moreira; L. M.B. Fonseca; S. A.L. Souza; B. Gutfilen

doi:10.1259/bjr.20150268

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Use of 99mTc-doxorubicin scintigraphy in females with breast cancer: A pilot study

Journal article

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Use of 99mTc-doxorubicin scintigraphy in females with breast cancer: A pilot study

F. I. Araujo, F. P.P. Proenca, C. G. Ferreira, S. C. Ventilari, P. H. Rosado De Castro, R. D. Moreira, L. M.B. Fonseca, S. A.L. Souza and B. Gutfilen

British journal of radiology, Vol.88(1052), 20150268

08/01/2015

DOI: 10.1259/bjr.20150268

PMID: 26111270

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https://www.ncbi.nlm.nih.gov/pmc/articles/4651371View

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Abstract

Objective: Doxorubicin (Eurofarma, São Paulo, Brazil) is an antitumour agent widely used in the treatment of breast cancer and can be used for tumour tracking when labelled with a radionuclide. Here, we present the results obtained with technetium-99m (99mTc)-doxorubicin, using the direct method, to evaluate its uptake in breast cancer. Methods: Four females with confirmed breast carcinoma diagnosis and breast image reporting and data system Category 5 on mammography underwent whole-body and thorax single-photon emission CT/CT imaging 1 and 3 h after 99mTc-doxorubicin administration. Results: We observed increased uptake in breast carcinoma lesions and elimination via renal and hepatic pathways. Conclusion: These preliminary results suggest that 99mTc-doxorubicin may be a promising radiopharmaceutical for the evaluation of patients with breast cancer. Further studies are ongoing. Advances in knowledge: To our knowledge, this is the first study to evaluate the use of a directly labelled doxorubicin tracer in humans. 99mTc-doxorubicin could provide information on the response of tumours to doxorubicin.

Details

Title: Subtitle: Use of 99mTc-doxorubicin scintigraphy in females with breast cancer: A pilot study
Creators: F. I. Araujo - Hospital Universitário Clementino Fraga Filho
F. P.P. Proenca - Hospital do Câncer III
C. G. Ferreira - Coordination of Clinical Research, National Cancer Institute, Rio de Janeiro, Brazil
S. C. Ventilari - Hospital do Câncer III
P. H. Rosado De Castro - Nuclear Medicine Section, National Cancer Institute, Rio de Janeiro, Brazil
R. D. Moreira - Hospital do Câncer III
L. M.B. Fonseca - Hospital Universitário Clementino Fraga Filho
S. A.L. Souza - Hospital Universitário Clementino Fraga Filho
B. Gutfilen - Hospital Universitário Clementino Fraga Filho
Resource Type: Journal article
Publication Details: British journal of radiology, Vol.88(1052), 20150268
DOI: 10.1259/bjr.20150268
PMID: 26111270
NLM abbreviation: Br J Radiol
ISSN: 0007-1285
eISSN: 1748-880X
Publisher: BRITISH INST RADIOLOGY
Grant note: Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
This study was supported by Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq).
Language: English
Date published: 08/01/2015
Academic Unit: Radiology
Record Identifier: 9985143553402771

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