Journal article
Use of Crotalidae equine immune F(ab')(2) antivenom for treatment of an Agkistrodon envenomation
Clinical toxicology (Philadelphia, Pa.), Vol.59(11), pp.1023-1026
11/02/2021
DOI: 10.1080/15563650.2021.1892718
PMID: 33703984
Abstract
Introduction
Anavip (F(ab')(2)AV) is a lyophilized F(ab')(2) immunoglobulin fragment derived from horses immunized with venom from Bothrops asper and Crotalus durissus. It was approved by the FDA in 2015 for treatment of North American rattlesnake envenomation but not for Agkistrodon envenomation. Published data regarding the efficacy and safety of Anavip in treating Agkistrodon envenomations is limited. We present a case of a patient treated with Anavip after confirmed Agkistrodon laticinctus envenomation.
Case details
A 77 year-old man was bitten on his fifth finger by a captive A. laticinctus. He was taken to a local emergency department where he received a 10 vial initial dose of F(ab')(2)AV for pain and swelling and was transferred. At the receiving facility, his pain had improved and his swelling had not progressed. Over the next 30 h, his platelets declined to 132,000/mm(3) and he received an additional 4 vials of F(ab')(2)AV. The remainder of his course was unremarkable with complete recovery by 3 months.
Discussion
This case provides an additional published datapoint on the use of this F(ab')(2)AV in the treatment of envenomation by Agkistrodon.
Details
- Title: Subtitle
- Use of Crotalidae equine immune F(ab')(2) antivenom for treatment of an Agkistrodon envenomation
- Creators
- B. Z. Wilson - University of ArizonaJ. Larsen - University of ArizonaG. Smelski - University of ArizonaS. Dudley - University of ArizonaF. M. Shirazi - University of Arizona
- Resource Type
- Journal article
- Publication Details
- Clinical toxicology (Philadelphia, Pa.), Vol.59(11), pp.1023-1026
- Publisher
- Taylor & Francis
- DOI
- 10.1080/15563650.2021.1892718
- PMID
- 33703984
- ISSN
- 1556-3650
- eISSN
- 1556-9519
- Number of pages
- 4
- Language
- English
- Date published
- 11/02/2021
- Academic Unit
- Emergency Medicine
- Record Identifier
- 9984296977702771
Metrics
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