Journal article
Use of Lipid-Based Nutrient Supplements by HIV-Infected Malawian Women during Lactation Has No Effect on Infant Growth from 0 to 24 Weeks
The Journal of nutrition, Vol.142(7), pp.1350-1356
07/01/2012
DOI: 10.3945/jn.111.155598
PMCID: 3374670
PMID: 22649265
Abstract
The Breastfeeding, Antiretrovirals, and Nutrition Study evaluated the effect of daily consumption of lipid-based nutrient supplements (LNS) by 2121 lactating, HIV-infected mothers on the growth of their exclusively breast-fed, HIV-uninfected infants from 0 to 24 wk. The study had a 2 x 3 factorial design. Malawian mothers with CD4(+) >= 250 cells/mm(3), hemoglobin >= 70 g/L, and BMI >= 17 kg/m(2) were randomized within 36 h of delivery to receive either no LNS or 140 g/d of LNS to meet lactation energy and protein needs, and mother-infant pairs were assigned to maternal antiretroviral drugs (ARV), infant ARV, or no ARV. Sex-stratified, longitudinal, random effects models were used to estimate the effect of the 6 study arms on infant weight, length, and BMI. Logistic regression models were used to calculate the odds of growth faltering [decline in weight-for-age Z-score (WAZ) or length-for-age Z-score (LAZ) >0.67] using the control arm as the reference. Although some differences between study arms emerged with increasing infant age in boys, there were no consistent effects of the maternal supplement across the 3 growth outcomes in longitudinal models. At the ages where differences were observed, the effects on weight and BMI were quite small (<= 200 g and <= 0.4 kg/m(2)) and unlikely to be of clinical importance. Overall, 21 and 340% of infants faltered in WAZ and LAZ, respectively. Maternal supplementation did not reduce the odds of infant weight or length faltering from 0 to 24 wk in any arm. These results indicate that blanket supplementation of HIV-infected lactating women may have little impact on infant growth. J. Nutr. 142: 1350-1356, 2012.
Details
- Title: Subtitle
- Use of Lipid-Based Nutrient Supplements by HIV-Infected Malawian Women during Lactation Has No Effect on Infant Growth from 0 to 24 Weeks
- Creators
- Valerie L. Flax - University of North Carolina at Chapel HillMargaret E. Bentley - University of North Carolina at Chapel HillCharles S. Chasela - University of the WitwatersrandDumbani Kayira - Univ N Carolina Project, Lilongwe, MalawiMichael G. Hudgens - University of North Carolina at Chapel HillRodney J. Knight - Principia CollegeAlice Soko - Univ N Carolina Project, Lilongwe, MalawiDenise J. Jamieson - Centers for Disease Control and PreventionCharles M. van der Horst - University of North Carolina at Chapel HillLinda S. Adair - University of North Carolina at Chapel Hill
- Resource Type
- Journal article
- Publication Details
- The Journal of nutrition, Vol.142(7), pp.1350-1356
- Publisher
- AMER SOC NUTRITION-ASN
- DOI
- 10.3945/jn.111.155598
- PMID
- 22649265
- PMCID
- 3374670
- ISSN
- 0022-3166
- eISSN
- 1541-6100
- Number of pages
- 7
- Grant note
- R24TW007988 / Fogarty International Clinical Research Fellows Program at Vanderbilt Elizabeth Glaser Pediatric AIDS Foundation DHHS/NIH/FIC 2-D43 Tw01039-06 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA U.S. Agency for International Development; United States Agency for International Development (USAID) Malawi Ministry of Health and Population, Johnson Johnson SIP 13-01 U48-CCU409660-09; SIP 26-04 U48-DP000059-01 / Prevention Research Centers Special Interest Project of the CDC NICHD 5 R24 HD050924 / Carolina Population Center GlaxoSmithKline Abbott Laboratories OPP53107 / Bill and Melinda Gates Foundation; Bill & Melinda Gates Foundation National Institute of Allergy and Infectious Diseases; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID) P30-Al50410 / University of North Carolina Center for AIDS Research United Nations Children's Fund
- Language
- English
- Date published
- 07/01/2012
- Academic Unit
- Obstetrics and Gynecology; VPMA - Administration
- Record Identifier
- 9984446517302771
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