Use of Sentinel Lymph Node Biopsy to Select Patients for Local–Regional Therapy After Neoadjuvant Chemotherapy

Lillian Erdahl; Judy Boughey

doi:10.1007/s12609-013-0135-7

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Use of Sentinel Lymph Node Biopsy to Select Patients for Local–Regional Therapy After Neoadjuvant Chemotherapy

Journal article

Open access

Peer reviewed

Use of Sentinel Lymph Node Biopsy to Select Patients for Local–Regional Therapy After Neoadjuvant Chemotherapy

Lillian Erdahl and Judy Boughey

Current breast cancer reports, Vol.6(1), pp.10-16

03/2014

DOI: 10.1007/s12609-013-0135-7

PMCID: PMC3966207

PMID: 24683440

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https://www.ncbi.nlm.nih.gov/pmc/articles/3966207View

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Abstract

Use of sentinel lymph node biopsy for axillary staging of patients with breast cancer treated with neoadjuvant chemotherapy has been widely debated. Questions arise regarding the accuracy of sentinel lymph node biopsy in axillary staging for these patients and its use to determine further local–regional therapy, including surgery and radiation therapy. For patients who are clinically node-negative at presentation, sentinel lymph node biopsy enables accurate staging of the axilla after neoadjuvant chemotherapy, and determination of which patients should go on to further axillary surgery and regional nodal radiation therapy. Importantly, performing axillary staging after completion of chemotherapy, rather than before chemotherapy, enables assessment of response to chemotherapy and the extent of residual disease. This information can assist the planning of adjuvant treatment. Recent data indicate that sentinel node biopsy can also be used to assess disease response after neoadjuvant chemotherapy for patients with clinical N1 disease at presentation.

Neoadjuvant chemotherapy

Medicine & Public Health

Sentinel lymph node biopsy

Pathological complete response

Oncology

Internal Medicine

Breast cancer

Surgical Oncology

Details

Title: Subtitle: Use of Sentinel Lymph Node Biopsy to Select Patients for Local–Regional Therapy After Neoadjuvant Chemotherapy
Creators: Lillian Erdahl - Mayo Clinic 200 First Street, SW Rochester MN 55905 USA
Judy Boughey - Mayo Clinic 200 First Street, SW Rochester MN 55905 USA
Resource Type: Journal article
Publication Details: Current breast cancer reports, Vol.6(1), pp.10-16
DOI: 10.1007/s12609-013-0135-7
PMID: 24683440
PMCID: PMC3966207
NLM abbreviation: Curr Breast Cancer Rep
ISSN: 1943-4588
eISSN: 1943-4596
Publisher: Springer US; Boston
Language: English
Date published: 03/2014
Academic Unit: Surgery
Record Identifier: 9984051585102771

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