Journal article
Use of Stem Cells in Wound Healing
Current dermatology reports, Vol.7(4), pp.278-286
2018
DOI: 10.1007/s13671-018-0233-x
Abstract
Purpose of Review
This review provides an overview of the principal stages of wound healing, the populations of endogenous and therapeutic stem cells, applications of stem cells in specific types of wounds, and current approaches of stem cell delivery for tissue regeneration.
Recent Findings
New uses of progenitor stem cells have been developed for the treatment of wounds. Stem cells improve wound healing through both local and paracrine effects. Stem cell populations of therapeutic utility include embryonic stem cells, induced pluripotent stem cells, adult bone marrow and adipose-derived mesenchymal stem cells, as well as stem cells from skin, cord blood, and extra fetal tissue. Induced pluripotent stem cells mitigate many of the ethical and immunogenic concerns related to use of embryonically derived stem cells.
Summary
Skin, the largest organ in the human body, serves as a protective barrier for mammals. Both aging and disease contribute to loss of skin barrier function, which can result in consequences such as chronic wounds. Recent advances in many types of stem cell therapy may revolutionize treatment of difficult wounds. Optimal techniques for obtaining and delivering stem cells are still being refined.
Details
- Title: Subtitle
- Use of Stem Cells in Wound Healing
- Creators
- Adam Aronson - University of IowaLeah Laageide - University of IowaJennifer Powers - University of Iowa Hospitals and Clinics
- Resource Type
- Journal article
- Publication Details
- Current dermatology reports, Vol.7(4), pp.278-286
- Publisher
- Springer US
- DOI
- 10.1007/s13671-018-0233-x
- ISSN
- 2162-4933
- eISSN
- 2162-4933
- Language
- English
- Date published
- 2018
- Academic Unit
- Dermatology
- Record Identifier
- 9984368081902771
Metrics
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