Journal article
Use of Vasopressin in Neonatal Intensive Care Unit Patients With Hypotension
The journal of pediatric pharmacology and therapeutics, Vol.22(6), pp.430-435
12/01/2017
DOI: 10.5863/1551-6776-22.6.430
PMCID: PMC5736255
PMID: 29290743
Abstract
OBJECTIVE To evaluate the safety and efficacy of vasopressin for the treatment of hypotension in patients admitted to neonatal intensive care units (NICUs).
METHODS Vasopressin use in 69 infants admitted to our NICU between 2011 and 2014 was examined. Data evaluated included demographics; serum creatinine, sodium, and lactate concentrations; urine output; and systolic, diastolic, and mean blood pressures (BPs). Parameters prior to vasopressin use were compared to those at maximum dose.
RESULTS Vasopressin use was associated with increased urine output (p < 0.05), and increased systolic (p < 0.0005), diastolic (p < 0.01), and mean (p < 0.001) BP. There were no differences in sodium or lactate concentrations before vs during infusion; vasopressin use was not associated with hyponatremia (sodium < 130 mEq/L) at the maximum dose.
CONCLUSIONS Vasopressin for the treatment of neonatal hypotension appears safe and was efficacious in raising BP. These data suggest that vasopressin could be considered a viable option in the treatment regimen in hypotensive infants in the NICU.
Details
- Title: Subtitle
- Use of Vasopressin in Neonatal Intensive Care Unit Patients With Hypotension
- Creators
- Mengwei Ni - The University of Texas Health Science Center at HoustonJeffrey R. Kaiser - The University of Texas Health Science Center at HoustonBrady S. Moffett - The University of Texas Health Science Center at HoustonChristopher J. Rhee - The University of Texas Health Science Center at HoustonJennifer Placencia - The University of Texas Health Science Center at HoustonKimberly L. Dinh - The University of Texas Health Science Center at HoustonJoseph L. Hagan - The University of Texas Health Science Center at HoustonDanielle R. Rios - The University of Texas Health Science Center at Houston
- Resource Type
- Journal article
- Publication Details
- The journal of pediatric pharmacology and therapeutics, Vol.22(6), pp.430-435
- DOI
- 10.5863/1551-6776-22.6.430
- PMID
- 29290743
- PMCID
- PMC5736255
- ISSN
- 1551-6776
- eISSN
- 2331-348X
- Language
- English
- Date published
- 12/01/2017
- Academic Unit
- Stead Family Department of Pediatrics; Neonatology
- Record Identifier
- 9984354002702771
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