Use of agricultural pesticides and prostate cancer risk in the Agricultural Health Study cohort

Michael C R Alavanja; Claudine Samanic; Mustafa Dosemeci; Jay Lubin; Robert Tarone; Charles F Lynch; Charles Knott; Kent Thomas; Jane A Hoppin; Joseph Barker; Joseph Coble; Dale P Sandler; Aaron Blair

doi:10.1093/aje/kwg040

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Use of agricultural pesticides and prostate cancer risk in the Agricultural Health Study cohort

Journal article

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Peer reviewed

Use of agricultural pesticides and prostate cancer risk in the Agricultural Health Study cohort

Michael C R Alavanja, Claudine Samanic, Mustafa Dosemeci, Jay Lubin, Robert Tarone, Charles F Lynch, Charles Knott, Kent Thomas, Jane A Hoppin, Joseph Barker, …

American journal of epidemiology, Vol.157(9), pp.800-814

05/01/2003

DOI: 10.1093/aje/kwg040

PMID: 12727674

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https://doi.org/10.1093/aje/kwg040View

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Abstract

The authors examined the relation between 45 common agricultural pesticides and prostate cancer incidence in a prospective cohort study of 55,332 male pesticide applicators from Iowa and North Carolina with no prior history of prostate cancer. Data were collected by means of self-administered questionnaires completed at enrollment (1993-1997). Cancer incidence was determined through population-based cancer registries from enrollment through December 31, 1999. A prostate cancer standardized incidence ratio was computed for the cohort. Odds ratios were computed for individual pesticides and for pesticide use patterns identified by means of factor analysis. A prostate cancer standardized incidence ratio of 1.14 (95% confidence interval: 1.05, 1.24) was observed for the Agricultural Health Study cohort. Use of chlorinated pesticides among applicators over 50 years of age and methyl bromide use were significantly associated with prostate cancer risk. Several other pesticides showed a significantly increased risk of prostate cancer among study subjects with a family history of prostate cancer but not among those with no family history. Important family history-pesticide interactions were observed.

Age Distribution

Humans

Middle Aged

Agricultural Workers' Diseases - epidemiology

Prostatic Neoplasms - etiology

Male

Incidence

Prostatic Neoplasms - epidemiology

Pesticides - classification

Adult

Iowa - epidemiology

Surveys and Questionnaires

Aged

Pesticides - adverse effects

Agricultural Workers' Diseases - etiology

Odds Ratio

North Carolina - epidemiology

Prostatic Neoplasms - chemically induced

Agricultural Workers' Diseases - chemically induced

Cohort Studies

Details

Title: Subtitle: Use of agricultural pesticides and prostate cancer risk in the Agricultural Health Study cohort
Creators: Michael C R Alavanja - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20892, USA. alavanjm@mail.nih.gov
Claudine Samanic
Mustafa Dosemeci
Jay Lubin
Robert Tarone
Charles F Lynch
Charles Knott
Kent Thomas
Jane A Hoppin
Joseph Barker
Joseph Coble
Dale P Sandler
Aaron Blair
Resource Type: Journal article
Publication Details: American journal of epidemiology, Vol.157(9), pp.800-814
Publisher: United States
DOI: 10.1093/aje/kwg040
PMID: 12727674
ISSN: 0002-9262
eISSN: 1476-6256
Language: English
Date published: 05/01/2003
Academic Unit: Epidemiology
Record Identifier: 9983996075802771

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