Use of chemoprotectants in chemotherapy and radiation therapy: the challenges of selecting an appropriate agent

Gopabandhu Jena; Ajit Vikram; Durga Nand Tripathi; Poduri Ramarao

doi:10.1177/1534735410376633

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Use of chemoprotectants in chemotherapy and radiation therapy: the challenges of selecting an appropriate agent

Journal article

Peer reviewed

Use of chemoprotectants in chemotherapy and radiation therapy: the challenges of selecting an appropriate agent

Gopabandhu Jena, Ajit Vikram, Durga Nand Tripathi and Poduri Ramarao

Integrative cancer therapies, Vol.9(3), pp.253-258

09/2010

DOI: 10.1177/1534735410376633

PMID: 20702492

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Abstract

Chemoprotection refers to the protection from the toxicity of one chemical by the intervention of another. Conflicting preclinical and clinical reports make it difficult to either ignore or accept the use of chemoprotectants during cancer chemotherapy or radiotherapy. The selection of anticancer drugs depends on the type and stage of cancer development. However, very little attention has been paid to the selection of chemoprotectants. The answer to the use of chemoprotectants during cancer therapy lies in their appropriate selection in a case-specific and/or issue-specific manner. The need of the hour is to find better answers on the rationality of chemoprotectants selection during cancer therapy using cutting-edge science. In this commentary, we have presented few examples to justify our view-points.

Antineoplastic Agents - therapeutic use

Antioxidants - therapeutic use

Dietary Supplements

Humans

Neoplasm Staging

Neoplasms - drug therapy

Neoplasms - radiotherapy

Protective Agents - therapeutic use

Radiation-Sensitizing Agents

Randomized Controlled Trials as Topic

Details

Title: Subtitle: Use of chemoprotectants in chemotherapy and radiation therapy: the challenges of selecting an appropriate agent
Creators: Gopabandhu Jena - National Institute of Pharmaceutical Education and Research
Ajit Vikram - National Institute of Pharmaceutical Education and Research (NIPER), Mohali, Punjab, India
Durga Nand Tripathi - National Institute of Pharmaceutical Education and Research (NIPER), Mohali, Punjab, India
Poduri Ramarao - National Institute of Pharmaceutical Education and Research (NIPER), Mohali, Punjab, India
Resource Type: Journal article
Publication Details: Integrative cancer therapies, Vol.9(3), pp.253-258
DOI: 10.1177/1534735410376633
PMID: 20702492
NLM abbreviation: Integr Cancer Ther
ISSN: 1534-7354
eISSN: 1552-695X
Language: English
Date published: 09/2010
Academic Unit: Cardiovascular Medicine; Fraternal Order of Eagles Diabetes Research Center; Internal Medicine
Record Identifier: 9984359922602771

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