Use of convalescent plasma for COVID-19 in India: A review & practical guidelines

Niranjan Shiwaji Khaire; Nishant Jindal; Lakshmi Narayana Yaddanapudi; Suchet Sachdev; Rekha Hans; Naresh Sachdeva; Mini P Singh; Anup Agarwal; Aparna Mukherjee; Gunjan Kumar; Ratti Ram Sharma; Vikas Suri; Goverdhan Dutt Puri; Pankaj Malhotra

doi:10.4103/ijmr.IJMR_3092_20

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Use of convalescent plasma for COVID-19 in India: A review & practical guidelines

Journal article

Peer reviewed

Use of convalescent plasma for COVID-19 in India: A review & practical guidelines

Niranjan Shiwaji Khaire, Nishant Jindal, Lakshmi Narayana Yaddanapudi, Suchet Sachdev, Rekha Hans, Naresh Sachdeva, Mini P Singh, Anup Agarwal, Aparna Mukherjee, Gunjan Kumar, …

Indian journal of medical research (New Delhi, India : 1994), Vol.153(1 & 2), pp.64-85

01/2021

DOI: 10.4103/ijmr.IJMR_3092_20

PMID: 33818467

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Abstract

Convalescent plasma (CP) therapy is one of the promising therapies being tried for COVID-19 patients. This passive immunity mode involves separating preformed antibodies against SARS-CoV-2 from a recently recovered COVID-19 patient and infusing it into a patient with active disease or an exposed individual for prophylaxis. Its advantages include ease of production, rapid deployment, specificity against the target infectious agent, and scalability. In the current pandemic, it has been used on a large scale across the globe and also in India. However, unequivocal proof of efficacy and effectiveness in COVID-19 is still not available. Various CP therapy parameters such as donor selection, antibody quantification, timing of use, and dosing need to be considered before its use. The current review attempts to summarize the available evidence and provide recommendations for setting up CP protocols in clinical and research settings.

Antibodies, Neutralizing

Antibodies, Viral

COVID-19 - therapy

COVID-19 Serotherapy

Humans

Immunization, Passive

India - epidemiology

Details

Title: Subtitle: Use of convalescent plasma for COVID-19 in India: A review & practical guidelines
Creators: Niranjan Shiwaji Khaire - Post Graduate Institute of Medical Education and Research
Nishant Jindal - Post Graduate Institute of Medical Education and Research
Lakshmi Narayana Yaddanapudi - Post Graduate Institute of Medical Education and Research
Suchet Sachdev - Post Graduate Institute of Medical Education and Research
Rekha Hans - Post Graduate Institute of Medical Education and Research
Naresh Sachdeva - Post Graduate Institute of Medical Education and Research
Mini P Singh - Post Graduate Institute of Medical Education and Research
Anup Agarwal - Indian Council of Medical Research
Aparna Mukherjee - Indian Council of Medical Research
Gunjan Kumar - Indian Council of Medical Research
Ratti Ram Sharma - Post Graduate Institute of Medical Education and Research
Vikas Suri - Post Graduate Institute of Medical Education and Research
Goverdhan Dutt Puri - Post Graduate Institute of Medical Education and Research
Pankaj Malhotra - Post Graduate Institute of Medical Education and Research
Resource Type: Journal article
Publication Details: Indian journal of medical research (New Delhi, India : 1994), Vol.153(1 & 2), pp.64-85
DOI: 10.4103/ijmr.IJMR_3092_20
PMID: 33818467
ISSN: 0971-5916
eISSN: 0975-9174
Language: English
Date published: 01/2021
Academic Unit: Internal Medicine
Record Identifier: 9985237502302771

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