Use of deep laryngeal oxygen insufflation during laryngoscopy in children: a randomized clinical trial

J.W. Steiner; D.I. Sessler; N. Makarova; E.J. Mascha; P.N. Olomu; J.W. Zhong; C.T. Setiawan; A.E. Handy; B.N. Kravitz; P. Szmuk

doi:10.1093/bja/aew186

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Use of deep laryngeal oxygen insufflation during laryngoscopy in children: a randomized clinical trial

Journal article

Open access

Peer reviewed

Use of deep laryngeal oxygen insufflation during laryngoscopy in children: a randomized clinical trial

J.W. Steiner, D.I. Sessler, N. Makarova, E.J. Mascha, P.N. Olomu, J.W. Zhong, C.T. Setiawan, A.E. Handy, B.N. Kravitz and P. Szmuk

British journal of anaesthesia : BJA, Vol.117(3), pp.350-357

09/2016

DOI: 10.1093/bja/aew186

PMID: 27466252

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Abstract

Brief periods of haemoglobin oxygen desaturation are common in children during induction of general anaesthesia. We tested the hypothesis that oxygen insufflation during intubation slows desaturation. Patients 1–17 yr old undergoing nasotracheal intubation were enrolled and randomly assigned to one of three groups: standard direct laryngoscopy (DL); laryngoscopy with Truview PCD videolaryngoscope (VLO2); or laryngoscopy with an oxygen cannula attached to the side of a standard laryngoscope (DLO2). The co-primary outcomes were time to 1% reduction in SpO2 from baseline, and the slope of overall desaturation vs time. All three groups were compared against each other. Data from 457 patients were available for the final analysis: 159 (35%) DL; 145 (32%) DLO2; and 153 (33%) VLO2. Both VLO2 and DLO2 were superior to DL in both time to a 1% reduction in SpO2 from baseline and the overall rate of desaturation (all P<0.001). The 25th percentile (95% confidence interval) of time to a 1% saturation decrease was 30 (24, 39) s for DL, 67 (35, 149) s for DLO2 and 75 (37, 122) s for VLO2. Mean desaturation slope was 0.13 (0.11, 0.15)% s−1 for DL, 0.04 (0.02, 0.06)% s−1 for DLO2 and 0.03 (0.004, 0.05)% s−1 for VLO2. We did not find a correlation between decrease in SpO2 percentage and BMI or age. Laryngeal oxygen insufflation increases the time to 1% desaturation and reduces the overall rate of desaturation during laryngoscopy in children. NCT01886807.

anesthesia

apnoeic oxygenation

laryngeal oxygen insufflation

nasotracheal intubation

paediatric patients

Details

Title: Subtitle: Use of deep laryngeal oxygen insufflation during laryngoscopy in children: a randomized clinical trial
Creators: J.W. Steiner - The University of Texas Southwestern Medical Center
D.I. Sessler - Cleveland Clinic
N. Makarova - Outcomes Research Consortium
E.J. Mascha - Outcomes Research Consortium
P.N. Olomu - The University of Texas Southwestern Medical Center
J.W. Zhong - The University of Texas Southwestern Medical Center
C.T. Setiawan - The University of Texas Southwestern Medical Center
A.E. Handy - The University of Texas Southwestern Medical Center
B.N. Kravitz - Medical City Children's Hospital
P. Szmuk - Outcomes Research Consortium
Resource Type: Journal article
Publication Details: British journal of anaesthesia : BJA, Vol.117(3), pp.350-357
DOI: 10.1093/bja/aew186
PMID: 27466252
NLM abbreviation: Br J Anaesth
ISSN: 0007-0912
eISSN: 1471-6771
Publisher: Elsevier Ltd
Language: English
Date published: 09/2016
Academic Unit: Anesthesia
Record Identifier: 9984656593002771

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