Journal article
Use of high dose naloxone in acute stroke: Possible side-effects
Critical care medicine, Vol.17(8), pp.762-767
08/1989
DOI: 10.1097/00003246-198908000-00009
PMID: 2752771
Abstract
The effects of high dose naloxone in humans have not been studied extensively. We treated 36 patients who had acute ischemic cerebral infarction with high doses of naloxone to evaluate potential efficacy and toxicity. All patients were treated with a 160-mg/m (4-mg/kg) loading dose followed by 80 mg/m h (2 mg/ kg h) ± 24 h. There were no statistically significant changes in group mean arterial pressure, respiratory rate, or heart rate in response to the loading dose or infusion, although clinically significant changes did occur in four patients. Twenty-three patients had adverse reactions possibly related to naloxone. the most common of which were nausea (n = 20), bradycardia and/ or hypotension (n = 3), myoclonus (n = 1), and hypertension (n = 1). Seven patients had naloxone discontinued for possible adverse reactions. All adverse reactions abated with discontinuation of naloxone and/or phar-macologic therapy when indicated. No deaths were attributable to naloxone treatment. High dose naloxone appears to be well tolerated in the majority of elderly patients with acute cerebral infarction.
Details
- Title: Subtitle
- Use of high dose naloxone in acute stroke: Possible side-effects
- Creators
- WILLIAM BARSAN - Form the Departments of Emergency Medicine (Drs. Barsan and Biros) and Neurology (Drs. Obnger and Brott, and Mr. Fberl, the University of OH: the Department of Neurology. University of Iowa, Iowa City. IA (Drs. Adams and Billert, and the Stroke and Irauma Program, National Institute of Neurological Disorders and Stroke. Bethesda, MD (Dr. Marler)CHARLES OLINGERHarold AdamsTHOMAS BROTTROBERT EBERLEJOSE BILLERMICHELLE BIROSJOHN MARLER
- Resource Type
- Journal article
- Publication Details
- Critical care medicine, Vol.17(8), pp.762-767
- Publisher
- Williams & Wilkins
- DOI
- 10.1097/00003246-198908000-00009
- PMID
- 2752771
- ISSN
- 0090-3493
- eISSN
- 1530-0293
- Language
- English
- Date published
- 08/1989
- Academic Unit
- Neurology; Iowa Neuroscience Institute
- Record Identifier
- 9984020988602771
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