Journal article
Use of intravenous immunoglobulin in the treatment of staphylococcal and streptococcal toxic shock syndromes and related illnesses
Journal of allergy and clinical immunology, Vol.108(4), pp.S107-S110
2001
DOI: 10.1067/mai.2001.117820
PMID: 11586276
Abstract
Pyrogenic toxin superantigens comprise a large family of exotoxins made by
Staphylococcus aureus and group A streptococci. These toxins include toxic shock syndrome toxin-1, the staphylococcal enterotoxins, and the streptococcal pyrogenic exotoxins (synonyms: scarlet fever toxins and erythrogenic toxins), all of which have the ability to cause toxic shock syndromes and related illnesses. These toxins have a similar three-dimensional structure that allows them to interact with relatively invariant regions of major histocompatibility complex class II molecules on the surface of antigen-presenting cells and with certain variable regions of the T-cell receptor-β chain. The consequence of these interactions (and other immunobiological properties of the toxins) is the exaggerated release of bioactive cytokines. The latter molecules are responsible for the clinical signs of illness associated with these toxins. (J Allergy Clin Immunol 2001;108:S107-10.)
Details
- Title: Subtitle
- Use of intravenous immunoglobulin in the treatment of staphylococcal and streptococcal toxic shock syndromes and related illnesses
- Creators
- Patrick M Schlievert - Department of Microbiology, University of Minnesota Medical School, Minneapolis, Minn
- Resource Type
- Journal article
- Publication Details
- Journal of allergy and clinical immunology, Vol.108(4), pp.S107-S110
- Publisher
- Mosby, Inc
- DOI
- 10.1067/mai.2001.117820
- PMID
- 11586276
- ISSN
- 0091-6749
- eISSN
- 1097-6825
- Language
- English
- Date published
- 2001
- Academic Unit
- Microbiology and Immunology; Internal Medicine
- Record Identifier
- 9984001114202771
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