Journal article
Use of iontophoresis for the treatment of cancer
Journal of controlled release, Vol.284, pp.144-151
08/28/2018
DOI: 10.1016/j.jconrel.2018.06.020
PMID: 29908892
Abstract
Despite major advancements in cancer treatments, there are still many limitations to therapy including off-target effects, drug resistance, and control of cancer-related symptoms. There are opportunities for local drug delivery devices to intervene at various stages of cancer to provide curative and palliative benefit. Iontophoretic devices that deliver drugs locally to a region of interest have been adapted for the treatment of cancer. These devices have shown promise in pre-clinical and clinical studies for retinoblastoma, skin, bladder, and pancreatic cancers. Herein, we review iontophoretic devices used in the management of cancer.
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•Iontophoretic devices have been used to deliver a variety of anti-cancer agents.•There are multiple routes of iontophoretic drug delivery for treatment of cancer.•Iontophoresis has been used in patients for treatment of bladder and skin cancers.•Translation of iontophoresis is contingent on finding the right clinical situation.
Details
- Title: Subtitle
- Use of iontophoresis for the treatment of cancer
- Creators
- James D Byrne - Harvard UniversityJen Jen Yeh - University of North Carolina at Chapel HillJoseph M DeSimone - University of North Carolina at Chapel Hill
- Resource Type
- Journal article
- Publication Details
- Journal of controlled release, Vol.284, pp.144-151
- Publisher
- Elsevier B.V
- DOI
- 10.1016/j.jconrel.2018.06.020
- PMID
- 29908892
- ISSN
- 0168-3659
- eISSN
- 1873-4995
- Grant note
- name: UNC Medical Scientists Training Program, award: NIGMS-2-T32-GM008719; name: PhRMA Foundation Fellowship
- Language
- English
- Date published
- 08/28/2018
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiation Oncology
- Record Identifier
- 9984274857302771
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