Journal article
Use of serum-specific immunoglobulins A and G for detection of Helicobacter pylori infection in patients with chronic gastritis by immunoblot analysis
Journal of clinical microbiology, Vol.35(12), pp.3058-3061
12/01/1997
DOI: 10.1128/jcm.35.12.3058-3061.1997
PMCID: PMC230122
PMID: 9399494
Abstract
Multiple invasive and noninvasive tests for detecting Helicobacter pylori infection are available. The current "gold standard" for the diagnosis of H. pylori infection requires histology and the rapid urease test. Our aim was to test the performance of immunoglobulin A (IgA) and IgG immunoblot assays in comparison with that of the gold standard tests for the diagnosis of H. pylori infection. Ninety patients who underwent gastroscopy were analyzed in a prospective study. Fifty-nine of them were defined to be H. pylori positive by the gold standard tests. The IgA and IgG immunoblot assays correctly identified H. pylori infection in 17 and 58 of these patients, respectively, indicating that determination of IgA antibodies seems to be of low diagnostic value for H. pylori infection. In contrast, the sensitivity and specificity of the IgG immunoblot assay were 98 and 71%, respectively, with positive and negative predictive values of 87 and 96%, respectively. Therefore, the IgG immunoblot assay proved to be a sensitive and useful, noninvasive test for the diagnosis of H. pylori infection.
Details
- Title: Subtitle
- Use of serum-specific immunoglobulins A and G for detection of Helicobacter pylori infection in patients with chronic gastritis by immunoblot analysis
- Creators
- S Karvar - University of WürzburgH Karch - University of WürzburgM Frosch - University of WürzburgW Burghardt - University of WürzburgU Gross - University of Würzburg
- Resource Type
- Journal article
- Publication Details
- Journal of clinical microbiology, Vol.35(12), pp.3058-3061
- DOI
- 10.1128/jcm.35.12.3058-3061.1997
- PMID
- 9399494
- PMCID
- PMC230122
- ISSN
- 0095-1137
- eISSN
- 1098-660X
- Language
- English
- Date published
- 12/01/1997
- Academic Unit
- Internal Medicine
- Record Identifier
- 9984695829702771
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