Journal article
Use of simeprevir following pre‐emptive pegylated interferon/ribavirin treatment for recurrent hepatitis C in living donor liver transplant recipients: a 12‐week pilot study
Journal of hepato-biliary-pancreatic sciences, Vol.22(2), pp.144-150
02/2015
DOI: 10.1002/jhbp.171
PMID: 25338946
Abstract
BackgroundThe management of recurrent hepatitis C following liver transplantation remains a challenge.
MethodsWe prospectively investigated the efficacy and safety of simeprevir in combination with pegylated interferon and ribavirin in five patients undergoing living donor liver transplantation (LDLT) with recurrent hepatitis due to hepatitis C virus (HCV) genotype 1b.
ResultsAs the immunosuppressive regimen, four received cyclosporine A (CsA) and one received tacrolimus (FK); no dose adjustment was made prior to the introduction of simeprevir, but the dose was accordingly modified afterwards. All five patients completed the intended 12‐week treatment course without significant adverse events greater than grade 2, and no episodes of rejection were detected during the study period. The trough levels of CsA and FK were stably maintained. At week 12, HCV‐RNA was not detectable in three of the five patients, whereas the HCV titer of the other two patients, including one with Q80L and V170I mutations at the HCV NS3 position, was at the lower level of quantification (1.2 log10 IU/ml).
ConclusionsBased on this pilot study, simeprevir‐based triple therapy is safe and somewhat effective within the first 12 weeks in LDLT recipients with HCV recurrence. Further studies are warranted to obtain robust conclusions.
Details
- Title: Subtitle
- Use of simeprevir following pre‐emptive pegylated interferon/ribavirin treatment for recurrent hepatitis C in living donor liver transplant recipients: a 12‐week pilot study
- Creators
- Tomohiro Tanaka - The University of Tokyo HospitalYasuhiko Sugawara - The University of TokyoNobuhisa Akamatsu - The University of TokyoJunichi Kaneko - The University of TokyoSumihito Tamura - The University of TokyoTaku Aoki - The University of TokyoYoshihiro Sakamoto - The University of TokyoKiyoshi Hasegawa - The University of TokyoMasayuki Kurosaki - Musashino Red Cross HospitalNamiki Izumi - Musashino Red Cross HospitalNorihiro Kokudo - The University of Tokyo
- Resource Type
- Journal article
- Publication Details
- Journal of hepato-biliary-pancreatic sciences, Vol.22(2), pp.144-150
- DOI
- 10.1002/jhbp.171
- PMID
- 25338946
- ISSN
- 1868-6974
- eISSN
- 1868-6982
- Number of pages
- 7
- Language
- English
- Date published
- 02/2015
- Academic Unit
- Gastroenterology and Hepatology; Internal Medicine
- Record Identifier
- 9984094361102771
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