Journal article
Use of steroids to suppress vascular response to radiation
International journal of radiation oncology, biology, physics, Vol.13(4), pp.563-567
1987
DOI: 10.1016/0360-3016(87)90072-1
PMID: 3558047
Abstract
A quantitative measure of the vascular permeability surface area product (PS) for albumin has been made using a double isotope technique. PS was significantly elevated in irradiated rat lung, heart, skin, and muscle, between 19 and 26 days following 18 or 25 Gray thorax irradiation. Administration of dexamethasone from 2 days before irradiation through the day of measurement suppressed the expected increase in PS in lung, heart, and muscle, but not in skin. Shorter periods of steroid administration were not as effective in suppressing this response to radiation exposure. Increased vascular permeability following radiation may be an essential element in the development of radiation fibrosis. We hypothesize that the ability to suppress this response could result in a long term reduction in the incidence of fibrosis.
Details
- Title: Subtitle
- Use of steroids to suppress vascular response to radiation
- Creators
- Margaret L EvansMichael M GrahamPeter A MahlerJanet S Rasey
- Resource Type
- Journal article
- Publication Details
- International journal of radiation oncology, biology, physics, Vol.13(4), pp.563-567
- DOI
- 10.1016/0360-3016(87)90072-1
- PMID
- 3558047
- NLM abbreviation
- Int J Radiat Oncol Biol Phys
- ISSN
- 0360-3016
- eISSN
- 1879-355X
- Publisher
- Elsevier Inc
- Language
- English
- Date published
- 1987
- Academic Unit
- Radiology; Radiation Oncology
- Record Identifier
- 9984046814202771
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