Journal article
Use of term reference infants in assessing the developmental outcome of extremely preterm infants: lessons learned in a multicenter study
Journal of perinatology, Vol.43(11), pp.1398-1405
11/2023
DOI: 10.1038/s41372-023-01729-x
PMCID: PMC10615749
PMID: 37542155
Abstract
OBJECTIVE Extremely preterm (EP) impairment rates are likely underestimated using the Bayley III norm-based thresholds scores and may be better assessed relative to concurrent healthy term reference (TR) infants born in the same hospital. STUDY DESIGN Blinded, certified examiners in the Neonatal Research Network (NRN) evaluated EP survivors and a sample of healthy TR infants recruited near the 2-year assessment age. RESULTS We assessed 1452 EP infants and 183 TR infants. TR-based thresholds showed higher overall EP impairment than Bayley norm-based thresholds (O.R. = 1.86; [95% CI 1.56-2.23], especially for severe impairment (36% vs. 24%; p ≤ 0.001). Difficulty recruiting TR patients at 2 years extended the study by 14 months and affected their demographics. CONCLUSION Impairment rates among EP infants appear to be substantially underestimated from Bayley III norms. These rates may be best assessed by comparison with healthy term infants followed with minimal attrition from birth in the same centers. CLINICALTRIALS GOV ID Term Reference (under the Generic Database Study): NCT00063063.
Details
- Title: Subtitle
- Use of term reference infants in assessing the developmental outcome of extremely preterm infants: lessons learned in a multicenter study
- Creators
- Charles E GreenJon E TysonRoy J HeyneSusan R HintzBetty R VohrCarla M BannAbhik DasEdward F BellSana Boral DebsareeaEmily Stephens - The University of Texas Health Science Center at HoustonMarie G GantzCarolyn M Petrie HuitemaKaren J JohnsonKristi L WatterbergRicardo MosqueraMyriam Peralta-CarcelenDeanne E Wilson-CostelloTarah T ColaizyNathalie L MaitreStephanie L MerharIra Adams-ChapmanJanell FullerMichelle E Hartley-McAndrewWilliam F MalcolmSarah WinterAndrea F DuncanGary J MyerStephen D KicklighterMyra H WyckoffSara B DeMauroAnna Maria HibbsBarbara J StollWaldemar A CarloKrisa P Van MeursMatthew A RysavyRavi M PatelPablo J SánchezAbbot R LaptookC Michael CottenCarl T D'AngioMichele C WalshEunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network
- Resource Type
- Journal article
- Publication Details
- Journal of perinatology, Vol.43(11), pp.1398-1405
- DOI
- 10.1038/s41372-023-01729-x
- PMID
- 37542155
- PMCID
- PMC10615749
- NLM abbreviation
- J Perinatol
- ISSN
- 0743-8346
- eISSN
- 1476-5543
- Grant note
- DOI: 10.13039/100009633, name: U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development, award: U10 HD21373, UG1 HD87229, U10 HD21373, UG1 HD87229, UG1 HD40689, UG1 HD27880, UG1 HD27904, U24 HD095254, U24 HD095254, UG1 HD53109, U24 HD095254, UG1 HD53109, UG1 HD53089, U10 HD21373, UG1 HD87229, UG1 HD34216, UG1 HD21364, UG1 HD53109, UG1 HD27851, UG1 HD27853, UG1 HD53089, UG1 HD87226, UG1 HD68244, UG1 HD40492, UG1 HD40689, UG1 HD68244, UG1 HD21364, U10 HD21373, UG1 HD87229, UG1 HD34216, UG1 HD53109, UG1 HD27904, UG1 HD40492, UG1 HD68263; name: U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development; name: U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development; name: U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development; name: U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development; name: U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development; DOI: 10.13039/100006108, name: U.S. Department of Health & Human Services | NIH | National Center for Advancing Translational Sciences, award: UL1 TR93, UL1 TR442, UL1 TR442, UL1 TR442, UL1 TR454, UL1 TR1117, UL1 TR105, UL1 TR1117, UL1 TR442, UL1 TR1117, UL1 TR42; name: U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development; name: U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development; name: U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development; name: U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development; name: U.S. Department of Health & Human Services | NIH | National Center for Advancing Translational Sciences; name: U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development; name: U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development; name: U.S. Department of Health & Human Services | NIH | National Center for Advancing Translational Sciences; name: U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development; name: U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development; name: U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development; name: U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development; name: U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development; name: U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development; name: U.S. Department of Health & Human Services | NIH | National Center for Advancing Translational Sciences; name: U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development; name: U.S. Department of Health & Human Services | NIH | National Center for Advancing Translational Sciences; name: U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development; name: U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development; name: U.S. Department of Health & Human Services | NIH | National Center for Advancing Translational Sciences; name: U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development; name: U.S. Department of Health & Human Services | NIH | National Center for Advancing Translational Sciences; name: U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development; name: U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development; name: U.S. Department of Health & Human Services | NIH | National Center for Advancing Translational Sciences; name: U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development; name: U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development; name: U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development; name: U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development; name: U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development; name: U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development; name: U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development; name: U.S. Department of Health & Human Services | NIH | National Center for Advancing Translational Sciences; name: U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development; name: U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development; name: U.S. Department of Health & Human Services | NIH | National Center for Advancing Translational Sciences; name: U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development; name: U.S. Department of Health & Human Services | NIH | National Center for Advancing Translational Sciences
- Language
- English
- Electronic publication date
- 08/04/2023
- Date published
- 11/2023
- Academic Unit
- Stead Family Department of Pediatrics; Neonatology
- Record Identifier
- 9984449660102771
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