Use of topiramate for spinal cord injury-related pain

Beth L Dinoff; J Scott Richards; Timothy J Ness

doi:10.1080/10790268.2003.11753712

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Use of topiramate for spinal cord injury-related pain

Journal article

Peer reviewed

Use of topiramate for spinal cord injury-related pain

Beth L Dinoff, J Scott Richards and Timothy J Ness

The journal of spinal cord medicine, Vol.26(4), pp.401-403

2003

DOI: 10.1080/10790268.2003.11753712

PMID: 14992343

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Abstract

Pain following spinal cord injury (SCI) has proved difficult to treat. Although the use of antiepileptic drugs to treat SCI-related pain has been studied previously, topiramate has not been investigated in this population. Our recent experience suggests that topiramate may be efficacious in the treatment of SCI-related pain. Case Studies Findings: This report presents the clinical histories of two people with pain following SCI who reported beneficial effects of treatment with the new antiepileptic drug topiramate, even after failing treatment with standard analgesic medications. Topiramate was well tolerated in these patients. For post-SCI pain, topiramate appears to be an effective treatment in some patients. Based on the present anecdotal findings, larger controlled studies comparing topiramate with standard treatment for SCI-related pain are warranted.

Pain, Intractable - drug therapy

Topiramate

Fructose - adverse effects

Drug Administration Schedule

Humans

Middle Aged

Spinal Cord Injuries - etiology

Anticonvulsants - therapeutic use

Male

Treatment Outcome

Cauda Equina - physiopathology

Fructose - therapeutic use

Dose-Response Relationship, Drug

Fructose - analogs & derivatives

Anticonvulsants - adverse effects

Adult

Spinal Cord Injuries - physiopathology

Drug Therapy, Combination

Pain Measurement

Cauda Equina - injuries

Details

Title: Subtitle: Use of topiramate for spinal cord injury-related pain
Creators: Beth L Dinoff - Rehabilitation Psychology, Department of Physical Medicine and Rehabilitation, University of Alabama at Birmingham, Birmingham, Alabama, USA
J Scott Richards
Timothy J Ness
Resource Type: Journal article
Publication Details: The journal of spinal cord medicine, Vol.26(4), pp.401-403
Publisher: England
DOI: 10.1080/10790268.2003.11753712
PMID: 14992343
ISSN: 1079-0268
eISSN: 2045-7723
Grant note: 5T32 HDO7420-11 / NICHD NIH HHS
Language: English
Date published: 2003
Academic Unit: Psychiatry; Anesthesia
Record Identifier: 9984006416502771

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9 Times Cited - Web of Science