Journal article
Use of topiramate in pregnancy and risk of oral clefts
American journal of obstetrics and gynecology, Vol.207(5), pp.405.e1-405.e7
11/2012
DOI: 10.1016/j.ajog.2012.07.008
PMCID: PMC3484193
PMID: 22917484
Abstract
The objective of this study was to evaluate the association between the use of monotherapy topiramate in pregnancy and cleft lip with or without cleft palate (CL/P) in the offspring.
Data from the Slone Epidemiology Center Birth Defects Study (BDS) from 1997 to 2009 and the National Birth Defects Prevention Study (NBDPS) from 1997 to 2007 were analyzed. Conditional logistic regression was used to compare the first-trimester use of topiramate monotherapy to no antiepileptic drug use during the periconceptional period between the mothers of infants with CL/P and the mothers of controls for each study separately and in pooled data.
The BDS contained 785 CL/P cases and 6986 controls; the NBDPS contained 2283 CL/P cases and 8494 controls. The odds ratios (exact 95% confidence intervals) for the association between topiramate use and CL/P were 10.1 (1.1-129.2) in the BDS, 3.6 (0.7-20.0) in the NBDPS, and 5.4 (1.5-20.1) in the pooled data.
First-trimester use of topiramate may be associated with CL/P.
Details
- Title: Subtitle
- Use of topiramate in pregnancy and risk of oral clefts
- Creators
- Andrea V Margulis - Department of Epidemiology, Harvard School of Public Health, Boston, MAAllen A Mitchell - Slone Epidemiology Center at Boston University, Boston, MASuzanne M Gilboa - National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GAMartha M Werler - Slone Epidemiology Center at Boston University, Boston, MAMurray A Mittleman - Department of Epidemiology, Harvard School of Public Health, Boston, MARobert J Glynn - Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women's Hospital, Boston, MASonia Hernandez-Diaz - Department of Epidemiology, Harvard School of Public Health, Boston, MANational Birth Defects Prevention Study
- Contributors
- Paul A Romitti (Contributor) - University of Iowa, Epidemiology
- Resource Type
- Journal article
- Publication Details
- American journal of obstetrics and gynecology, Vol.207(5), pp.405.e1-405.e7
- Publisher
- Mosby, Inc
- DOI
- 10.1016/j.ajog.2012.07.008
- PMID
- 22917484
- PMCID
- PMC3484193
- ISSN
- 0002-9378
- eISSN
- 1097-6868
- Grant note
- multiple pharmaceutical companies Pfizer R01 HD 046595 / Eunice Kennedy Shriver National Institute of Child Health and Human Development pharmaceutical companies Asisa
- Language
- English
- Date published
- 11/2012
- Academic Unit
- Epidemiology; Biostatistics
- Record Identifier
- 9984214692502771
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