Journal article
Uses of granulocyte-macrophage colony-stimulating factor in vaccine development
Current opinion in hematology, Vol.7(3), pp.168-173
05/2000
DOI: 10.1097/00062752-200005000-00007
PMID: 10786654
Abstract
Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a potent cytokine capable of inducing differentiation, proliferation, and activation of a variety of immunologically active cell populations. In addition to its effects on stimulating granulocytic hematopoiesis, it also facilitates development of both humoral and cellular mediated immunity. Accordingly, strategies involving the use of GM-CSF as a vaccine adjuvant have attracted considerable attention. These strategies include the systemic administration of soluble GM-CSF with an immunogen, and also its use as part of gene therapy approaches to immunization. Because of the potency of this cytokine as an immune adjuvant, particular interest has focused on its use to overcome poorly immunogenic antigens such as those associated with intracellular infections and cancer. This review focuses on recent advances in the use of GM-CSF as a vaccine adjuvant.
Details
- Title: Subtitle
- Uses of granulocyte-macrophage colony-stimulating factor in vaccine development
- Creators
- Thomas Warren - University of IowaGeorge Weiner
- Resource Type
- Journal article
- Publication Details
- Current opinion in hematology, Vol.7(3), pp.168-173
- Publisher
- Lippincott Williams & Wilkins, Inc
- DOI
- 10.1097/00062752-200005000-00007
- PMID
- 10786654
- ISSN
- 1065-6251
- eISSN
- 1531-7048
- Language
- English
- Date published
- 05/2000
- Academic Unit
- Hematology, Oncology, and Blood & Marrow Transplantation; Pharmaceutical Sciences and Experimental Therapeutics; Internal Medicine
- Record Identifier
- 9984360041802771
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