Using event-related potentials to study perinatal nutrition and brain development in infants of diabetic mothers

Raye-Ann deRegnier; Jeffrey D Long; Michael K Georgieff; Charles A Nelson

doi:10.1080/87565640701229524

Back

Using event-related potentials to study perinatal nutrition and brain development in infants of diabetic mothers

Journal article

Peer reviewed

Using event-related potentials to study perinatal nutrition and brain development in infants of diabetic mothers

Raye-Ann deRegnier, Jeffrey D Long, Michael K Georgieff and Charles A Nelson

Developmental neuropsychology, Vol.31(3), pp.379-396

2007

DOI: 10.1080/87565640701229524

PMCID: PMC2770716

PMID: 17559331

Files and links (1)

url

https://www.ncbi.nlm.nih.gov/pmc/articles/2770716View

Open Access

Abstract

Proper prenatal and postnatal nutrition is essential for optimal brain development and function. The early use of event-related potentials enables neuroscientists to study the development of cognitive function from birth and to evaluate the role of specific nutrients in development. Perinatal iron deficiency occurs in severely affected infants of diabetic mothers. In animal models, severe perinatal iron deficiency targets the explicit memory system of the brain. Cross-sectional ERP studies have shown that infants of diabetic mothers have impairments in recognition memory from birth through 8 months of age. The purpose of this study was to evaluate longitudinal development of recognition memory using ERPs in infants of diabetic mothers compared with control infants. Infants of diabetic mothers were divided into high and low risk status based upon their birth weights and iron status and compared with healthy control infants. Infants were tested in the newborn period for auditory recognition memory, at 6 months for visual recognition memory and at 8 months for cross modal memory. ERPs were evaluated for developmental changes in the slow waves that are thought to reflect memory and the Nc component that is thought to reflect attention. The results of the study showed differences in development between the IDMs and control infants in the development of the slow waves over the left anterior temporal leads and age-related patterns of development in the NC component. These results are consistent with animal models showing that perinatal iron deficiency affects the development of the memory networks of the brain. This study highlights the value of using ERPs to translate basic science information obtained from animal models to the development of the human infant.

Acoustic Stimulation - methods

Age Factors

Brain - growth & development

Evoked Potentials - physiology

Female

Humans

Infant

Infant Nutritional Physiological Phenomena

Longitudinal Studies

Male

Memory Disorders - diagnosis

Memory Disorders - etiology

Mothers

Neuropsychological Tests

Photic Stimulation - methods

Pregnancy

Pregnancy in Diabetics

Reaction Time - physiology

Recognition (Psychology) - physiology

Details

Title: Subtitle: Using event-related potentials to study perinatal nutrition and brain development in infants of diabetic mothers
Creators: Raye-Ann deRegnier - Northwestern University
Jeffrey D Long - University of Minnesota
Michael K Georgieff - University of Minnesota
Charles A Nelson - Harvard University
Resource Type: Journal article
Publication Details: Developmental neuropsychology, Vol.31(3), pp.379-396
DOI: 10.1080/87565640701229524
PMID: 17559331
PMCID: PMC2770716
NLM abbreviation: Dev Neuropsychol
ISSN: 8756-5641
eISSN: 1532-6942
Grant note: HD29421 / NICHD NIH HHS NS32755 / NINDS NIH HHS R29 HD029421 / NICHD NIH HHS R01 NS034458-12 / NINDS NIH HHS R01 HD029421 / NICHD NIH HHS R01 NS034458 / NINDS NIH HHS
Language: English
Date published: 2007
Academic Unit: Psychiatry; Biostatistics
Record Identifier: 9984280879302771

Metrics

21 Record Views

17 Times Cited - Web of Science