Using imaging as a biomarker for asthma

Abhaya Trivedi; Chase Hall; Eric A Hoffman; Jason C Woods; David S Gierada; Mario Castro

doi:10.1016/j.jaci.2016.11.009

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Journal article

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Peer reviewed

Using imaging as a biomarker for asthma

Abhaya Trivedi, Chase Hall, Eric A Hoffman, Jason C Woods, David S Gierada and Mario Castro

Journal of allergy and clinical immunology, Vol.139(1), pp.1-10

01/2017

DOI: 10.1016/j.jaci.2016.11.009

PMCID: PMC5224930

PMID: 28065276

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Abstract

There have been significant advancements in the various imaging techniques being used for the evaluation of asthmatic patients, both from a clinical and research perspective. Imaging characteristics can be used to identify specific asthmatic phenotypes and provide a more detailed understanding of endotypes contributing to the pathophysiology of the disease. Computed tomography, magnetic resonance imaging, and positron emission tomography can be used to assess pulmonary structure and function. It has been shown that specific airway and lung density measurements using computed tomography correlate with clinical parameters, including severity of disease and pathology, but also provide unique phenotypes. Hyperpolarized 129Xe and 3He are gases used as contrast media for magnetic resonance imaging that provide measurement of distal lung ventilation reflecting small-airway disease. Positron emission tomography can be useful to identify and target lung inflammation in asthmatic patients. Furthermore, imaging techniques can serve as a potential biomarker and be used to assess response to therapies, including newer biological treatments and bronchial thermoplasty.

biomarker

MRI

Imaging

PET

chest CT

Details

Title: Subtitle: Using imaging as a biomarker for asthma
Creators: Abhaya Trivedi - Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Washington University School of Medicine, St Louis, Mo
Chase Hall - Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Washington University School of Medicine, St Louis, Mo
Eric A Hoffman - Department of Biomedical Engineering, Department of Radiology, University of Iowa College of Medicine, Iowa City, Iowa
Jason C Woods - Center for Pulmonary Imaging Research, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio
David S Gierada - Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Washington University School of Medicine, St Louis, Mo
Mario Castro - Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Washington University School of Medicine, St Louis, Mo
Resource Type: Journal article
Publication Details: Journal of allergy and clinical immunology, Vol.139(1), pp.1-10
DOI: 10.1016/j.jaci.2016.11.009
PMID: 28065276
PMCID: PMC5224930
NLM abbreviation: J Allergy Clin Immunol
ISSN: 0091-6749
eISSN: 1097-6825
Publisher: Elsevier Inc
Language: English
Date published: 01/2017
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Radiology; Internal Medicine
Record Identifier: 9984051999202771

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