Journal article
Using multiple cutpoints for the free-to-total prostate specific antigen ratio improves the accuracy of prostate cancer detection
The Prostate, Vol.52(2), pp.150-158
07/01/2002
DOI: 10.1002/pros.10111
PMID: 12111706
Abstract
Background: Using a single cutpoint for the free-to-total (F/T) prostate specific antigen (PSA) ratio loses important diagnostic information. We evaluated the performance of multiple F/T PSA cutpoints in detecting prostate cancer in men with nonspecific PSA values.
Methods: We extracted sensitivity and specificity data from 12 studies reporting on >or=30 cancer patients with PSA values between 2.0 and 10.0 ng/mL. We calculated stratum-specific likelihood ratios (LR) and areas under the receiver operating characteristic (ROC) curves.
Results: Multiple cutpoints for the F/T PSA ratio significantly increased the area under the ROC (0.70) compared with the single investigator-selected cutpoint (0.62), P < 0.004. The LR for the most positive cutpoint stratum (2.62) was significantly higher than the LR for a positive test from the single cutpoint (1.36), P < 0.004.
Conclusions: Using multiple cutpoints increased the discriminating power of the F/T PSA ratio and led to greater probability revisions in the most positive test-result strata.
Details
- Title: Subtitle
- Using multiple cutpoints for the free-to-total prostate specific antigen ratio improves the accuracy of prostate cancer detection
- Creators
- Richard M Hoffman - Departments of Medicine, Albuquerque VA Medical Center, Albuquerque, New MexicoDavid L Clanon - Departments of Medicine, Albuquerque VA Medical Center, Albuquerque, New MexicoMargarita Chavez - University of New Mexico School of Medicine, Albuquerque, New MexicoJohn C Peirce - Department of Medical Education and Research, Good Samaritan Regional Medical Center, Phoenix, Arizona
- Resource Type
- Journal article
- Publication Details
- The Prostate, Vol.52(2), pp.150-158
- Publisher
- Wiley Subscription Services, Inc., A Wiley Company
- DOI
- 10.1002/pros.10111
- PMID
- 12111706
- ISSN
- 0270-4137
- eISSN
- 1097-0045
- Number of pages
- 9
- Language
- English
- Date published
- 07/01/2002
- Academic Unit
- Epidemiology; General Internal Medicine; Internal Medicine
- Record Identifier
- 9984094538102771
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