Journal article
Using pharmacokinetics for tailoring prophylaxis in people with hemophilia switching between clotting factor products: A scoping review
Research and practice in thrombosis and haemostasis, Vol.3(3), pp.528-541
05/20/2019
DOI: 10.1002/rth2.12204
PMCID: PMC6611373
PMID: 31294337
Abstract
The objective of this scoping review is to summarize the current use of pharmacokinetics for tailoring prophylaxis in hemophilia patients switching between clotting factor products. Patients with hemophilia may require switching of clotting factor concentrates due to a variety of factors, but there have been perceived risks associated with switching, such as inhibitor development or suboptimal protection due to inadequate dosing while titrating treatment. Studies that look at patients switching from one clotting factor concentrate to another are categorized in terms of their primary and/or secondary objectives, notably biosimilarity and comparative pharmacokinetic studies and inhibitor development studies. Research on how best to switch concentrates with respect to dosing regimen are lacking, and currently a trial‐and‐error approach is used for dosing the new factor concentrate. In the future, studies looking at the predictability of pharmacokinetics (
PK
) of a new factor concentrate based on individual
PK
knowledge of the original factor concentrate may offer clinical benefit by providing a safer switching approach and protocol.
Details
- Title: Subtitle
- Using pharmacokinetics for tailoring prophylaxis in people with hemophilia switching between clotting factor products: A scoping review
- Creators
- Jacky K. Yu - University of WaterlooAlfonso Iorio - McMaster UniversityAndrea N. Edginton - University of WaterlooWAPPS co‐investigators
- Contributors
- Anjali Sharathkumar (Contributor) - University of Iowa, Hematology/Oncology
- Resource Type
- Journal article
- Publication Details
- Research and practice in thrombosis and haemostasis, Vol.3(3), pp.528-541
- Publisher
- John Wiley and Sons Inc
- DOI
- 10.1002/rth2.12204
- PMID
- 31294337
- PMCID
- PMC6611373
- ISSN
- 2475-0379
- eISSN
- 2475-0379
- Language
- English
- Date published
- 05/20/2019
- Academic Unit
- Stead Family Department of Pediatrics; Hematology/Oncology
- Record Identifier
- 9984354155402771
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