Journal article
Using the Pediatric Patient-reported Outcomes–common Terminology Criteria for Adverse Events to Longitudinally Measure Symptom Adverse Events of Children With Advanced Cancer
Cancer care research online, Vol.2(2), e020
04/2022
DOI: 10.1097/CR9.0000000000000020
Abstract
Background: Children with advanced cancer are frequently enrolled on clinical trials and experience multiple symptoms. Inclusion of patient-reported outcomes in pediatric cancer trials to monitor for symptom adverse events (AEs) of treatment is limited. Objective: To (1) determine the feasibility and acceptability of administering the Ped-PRO-CTCAE biweekly over a 6-month period to children with advanced cancer, and (2) describe symptom AEs. Interventions/Methods: A multisite prospective longitudinal design was used to electronically collect information about symptom AEs using the Ped-PRO-CTCAE and acceptability of a biweekly assessment interval in children 2–18 of age with a diagnosis of advanced cancer who spoke English or Spanish. Descriptive statistics were used to analyze sample characteristics and symptom AE data. Results: Forty-nine children completed the study with a mean age of 11.1 years with diverse cancer diagnoses. Participants completed 85% of 515 administered symptom measures over an average of 16 weeks. Fatigue severity and frequency attributes for anxiety, pain, nausea, and anorexia were the most reported symptom AEs across all participants and time points, while severity attributes of pain, nausea, headache, and abdominal pain had the highest mean scores. Conclusions: Biweekly electronic symptom assessment using the Pediatric PRO-CTCAE is feasible and acceptable. Implications for Practice: Using the Ped-PRO-CTCAE to longitudinally measure symptom AEs in children with advanced cancer may support clinicians and researchers alike to understand patient-reported symptom experiences and toxicities from treatment across the continuum of care. What is Foundational: Inclusion of patient-reported symptom AE monitoring in therapeutic and nontherapeutic clinical trials is necessary to illuminate symptom experiences.
Details
- Title: Subtitle
- Using the Pediatric Patient-reported Outcomes–common Terminology Criteria for Adverse Events to Longitudinally Measure Symptom Adverse Events of Children With Advanced Cancer
- Creators
- Kathleen E. Montgomery - University of Wisconsin–MadisonJennifer L. Raybin - University of Colorado DenverJessica Ward - Children's Hospital of Los AngelesKrista Grinde - University of Wisconsin–MadisonCorey Smith - University of Wisconsin–MadisonRoger Brown - University of Wisconsin–Madison
- Resource Type
- Journal article
- Publication Details
- Cancer care research online, Vol.2(2), e020
- DOI
- 10.1097/CR9.0000000000000020
- ISSN
- 2691-3623
- eISSN
- 2691-3623
- Language
- English
- Date published
- 04/2022
- Academic Unit
- Stead Family Department of Pediatrics; Hematology/Oncology
- Record Identifier
- 9984701747102771
Metrics
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