Journal article
Using the laboratory to predict thrombosis in dogs: An achievable goal?
The veterinary journal (1997), Vol.215, pp.10-20
09/2016
DOI: 10.1016/j.tvjl.2016.03.027
PMID: 27105767
Abstract
•Thrombosis causes significant mortality; but anti-coagulants can cause bleeding.•Laboratory tests that identify thrombotic-risk would allow individualized therapy.•D-dimers, aPTT, thromboelastography and microparticles may predict risk in humans.•Canine risk prediction models will require careful development and validation.
Thrombosis is a major cause of mortality and morbidity in humans and dogs; however, anti-thrombotic drugs carry a risk of bleeding and increase the cost of patient care. The ability to identify individuals at high risk of thrombosis would allow targeting of anti-coagulant therapy at those most likely to derive a net benefit. Significant advances have been made towards predicting thrombotic risk in humans using laboratory tests individually and as part of risk prediction models. Assays that have shown potential in humans include D-dimers, activated partial thromboplastin time and viscoelastic testing, all of which are available to veterinarians. This review discusses the extent to which these assays are likely to predict thrombosis in dogs, and introduces new research techniques which may have future clinical value.
Details
- Title: Subtitle
- Using the laboratory to predict thrombosis in dogs: An achievable goal?
- Creators
- Unity Jeffery - Department of Veterinary Microbiology and Preventative Medicine, College of Veterinary Medicine, Iowa State University, Ames, IA 50011, USAJanice Staber - Pappajohn Biomedical Institute and Stead Family Department of Pediatrics, University of Iowa, Iowa City, IA 52242, USADana LeVine - Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Iowa State University, Ames, IA 50011, USA
- Resource Type
- Journal article
- Publication Details
- The veterinary journal (1997), Vol.215, pp.10-20
- Publisher
- Elsevier Ltd
- DOI
- 10.1016/j.tvjl.2016.03.027
- PMID
- 27105767
- ISSN
- 1090-0233
- eISSN
- 1532-2971
- Language
- English
- Date published
- 09/2016
- Academic Unit
- Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Hematology/Oncology
- Record Identifier
- 9984065821202771
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