Journal article
Uterine artery embolization in sheep: comparison of acute effects with Embosphere microspheres and Embosoft microspheres
Acta radiologica (1987), Vol.66(11), pp.1159-1164
11/01/2025
DOI: 10.1177/02841851251355583
PMID: 40635612
Abstract
Background
Embolization plays a significant role in interventional radiology and modern medicine, intersecting with several specialties. The technological advancement of embolic agents has contributed to successful outcomes in the treatment of a wide range of diseases.
Purpose
To compare the histomorphological effects of Embosoft microspheres and Embosphere microspheres in uterine artery embolization (UAE) in sheep.
Material and Methods
Superselective and bilateral UAE was performed with Embosoft and Embosphere microspheres in 10 adult non-pregnant sheep. Embosoft microspheres with a diameter of 500–700 μm were compared with Embosphere microspheres of a similar diameter in two groups of five sheep each. One sheep was embolized only with non-ionic iodinated contrast solution and saline (SF0.9%). The evaluation was based on histopathological examination of the uterus, performed 7 days after embolization. Necrosis scores, the diameter of occluded arteries, and the number of particles were assessed. ANOVA test and Student's t-test were used to determine the differences between the study groups.
Results
The mean volume of embolic agents was 18.35 mL in the Embosphere group and 19.1 mL in the Embosoft group, with no statistically significant difference (P = 0.62). No significant difference was observed between the corresponding sides in the two groups. In addition, there were no significant differences in the thickness of the surface epithelium (Embosphere 21.26 μm vs. 19.72 μm Embosoft; P = 0.56) and glandular area between the groups (Embosphere 12.20% vs. 17.77% Embosoft; P = 0.18).
Conclusion
Embosoft micropheres were associated with a greater inflammatory response and a smaller area of degeneration compared to Embosphere microspheres.
Details
- Title: Subtitle
- Uterine artery embolization in sheep: comparison of acute effects with Embosphere microspheres and Embosoft microspheres
- Creators
- Túlio Fabiano de Oliveira Leite - Universidade de São PauloMarcos de Lorenzo Messina - Universidade de São PauloCelso Kiyochi Takimura - Universidade de São PauloMira Zlotnik Finkelstein - Hospital das Clínicas da Faculdade de Medicina da Universidade de São PauloJose Maria Soares Júnior - Universidade de São PauloJoaquim Maurício Da Motta Leal Filho - Universidade de São Paulo
- Resource Type
- Journal article
- Publication Details
- Acta radiologica (1987), Vol.66(11), pp.1159-1164
- DOI
- 10.1177/02841851251355583
- PMID
- 40635612
- NLM abbreviation
- Acta Radiol
- ISSN
- 0284-1851
- eISSN
- 1600-0455
- Number of pages
- 6
- Language
- English
- Date published
- 11/01/2025
- Academic Unit
- Radiology
- Record Identifier
- 9985180933502771
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