Utility of 3-Month Surveillance F-18 FDG PET/CT in Surgically Resected Oral Squamous Cell Carcinoma

Michael Marquardt; Carryn Anderson; Timothy Ginader; Jessica Parkhurst; Nitin Pagedar; Rodrigo Bayon; Gerald Clamon; Andrew Hoover; John Buatti

doi:10.1177/0003489417751474

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Utility of 3-Month Surveillance F-18 FDG PET/CT in Surgically Resected Oral Squamous Cell Carcinoma

Journal article

Peer reviewed

Utility of 3-Month Surveillance F-18 FDG PET/CT in Surgically Resected Oral Squamous Cell Carcinoma

Michael Marquardt, Carryn Anderson, Timothy Ginader, Jessica Parkhurst, Nitin Pagedar, Rodrigo Bayon, Gerald Clamon, Andrew Hoover and John Buatti

Annals of otology, rhinology & laryngology, Vol.127(3), pp.185-191

03/2018

DOI: 10.1177/0003489417751474

PMCID: PMC6445268

PMID: 29313371

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https://www.ncbi.nlm.nih.gov/pmc/articles/6445268View

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Abstract

To evaluate the performance of surveillance F-18 fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) 1 year after imaging in oral squamous cell carcinoma (OSCC) patients treated with definitive surgery and adjuvant (chemo)radiotherapy (RT). Surveillance PET/CT accuracy was retrospectively evaluated in OSCC patients receiving surgical resection and (chemo)RT. Pathologic risk factors were assessed for influence on accuracy of the post-RT PET/CT. Fifty-four patients with median follow-up of 3.8 years met inclusion criteria. A PET/CT obtained a median of 3.4 months after RT revealed 11 (20.4%) instances of true disease recurrence: 4 locoregional alone, 6 distant alone, and 1 patient with locoregional and distant disease. Locoregional detection sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were 55.6%, 75.0%, 33.3%, and 88.2%, respectively. For distant recurrence, the respective values were 100%, 95.2%, 77.8%, and 100%. Absence of bone invasion, absence of pT4 disease, and disease within the tongue were independently associated with higher sensitivity ( P = .048). Perineural invasion was associated with increased specificity ( P = .027), and tumor location in the tongue was associated with a higher PPV ( P = .007) on surveillance PET/CT. Post-RT PET/CT accuracy information for surgically managed OSCC patients demonstrates significant associations with pathologic factors.

Carcinoma, Squamous Cell - epidemiology

Neoplasm Invasiveness

Carcinoma, Squamous Cell - pathology

Humans

Middle Aged

Head and Neck Neoplasms - therapy

Carcinoma, Squamous Cell - therapy

Tomography, X-Ray Computed - methods

Male

Dimensional Measurement Accuracy

Neoplasm Recurrence, Local - diagnosis

Neck Dissection - methods

Chemoradiotherapy, Adjuvant - methods

Head and Neck Neoplasms - pathology

Multimodal Imaging

Head and Neck Neoplasms - epidemiology

Female

Iowa - epidemiology

Aged

Fluorodeoxyglucose F18 - pharmacology

Retrospective Studies

Radiopharmaceuticals - pharmacology

Surgical Procedures, Operative - methods

Positron Emission Tomography Computed Tomography - methods

Details

Title: Subtitle: Utility of 3-Month Surveillance F-18 FDG PET/CT in Surgically Resected Oral Squamous Cell Carcinoma
Creators: Michael Marquardt - 1 Department of Radiation Oncology, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA
Carryn Anderson - 1 Department of Radiation Oncology, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA
Timothy Ginader - 2 Department of Biostatistics, University of Iowa College of Public Health, Iowa City, Iowa, USA
Jessica Parkhurst - 1 Department of Radiation Oncology, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA
Nitin Pagedar - 3 Department of Otolaryngology, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA
Rodrigo Bayon - 3 Department of Otolaryngology, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA
Gerald Clamon - 4 Department of Internal Medicine, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA
Andrew Hoover - 5 Department of Radiation Oncology, University of Kansas Medical Center, Kansas City, Kansas, USA
John Buatti - 1 Department of Radiation Oncology, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA
Resource Type: Journal article
Publication Details: Annals of otology, rhinology & laryngology, Vol.127(3), pp.185-191
DOI: 10.1177/0003489417751474
PMID: 29313371
PMCID: PMC6445268
NLM abbreviation: Ann Otol Rhinol Laryngol
ISSN: 1943-572X
eISSN: 1943-572X
Publisher: United States
Grant note: P30 CA086862 / NCI NIH HHS U01 CA140206 / NCI NIH HHS
Language: English
Date published: 03/2018
Academic Unit: Hematology, Oncology, and Blood & Marrow Transplantation; Radiation Oncology; Neurosurgery; Otolaryngology; Internal Medicine
Record Identifier: 9984006361002771

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