Journal article
Utility of Virtual Crossmatch in Sensitized Patients Awaiting Heart Transplantation
The Journal of heart and lung transplantation, Vol.28(11), pp.1129-1134
11/01/2009
DOI: 10.1016/j.healun.2009.05.031
PMID: 19782589
Abstract
Background: Organ transplant candidates with serum antibodies directed against human leukocyte antigens (HLA) face longer waiting times and higher mortality while awaiting transplantation. This study examined the accuracy of virtual crossmatch, in which recipient HLA-specific antibodies, identified by solid-phase assays, are compared to the prospective donor HLA-type in heart transplantation.
Methods: We examined the accuracy of virtual crossmatch in predicting immune compatibility of donors and recipients in heart transplantation and clinical outcomes in immunologically sensitized heart transplant recipients in whom virtual crossmatch was used in allograft allocation.
Results: Based on analysis of 257 T-cell antihuman immunoglobulin complement-dependent cytotoxic (AHG-CDC) crossmatch tests, the positive predictive value of virtual crossmatch (the likelihood of an incompatible virtual crossmatch resulting in an incompatible T-cell CDC-AHG crossmatch) was 79%, and the negative predictive value of virtual crossmatch (the likelihood of a compatible virtual crossmatch resulting in a compatible T-cell CDC-AHG crossmatch) was 92%. When used in a cohort of 28 sensitized patients awaiting heart transplantation, 14 received allografts based on a compatible virtual crossmatch alone from donors in geographically distant locations. Compared with the other 14 sensitized patients who underwent transplant after a compatible prospective serologic crossmatch, the rejection rates and survival were similar.
Conclusion: Our findings are evidence of the accuracy of virtual crossmatch and its utility in augmenting the opportunities for transplantation of sensitized patients. J Heart Lung Transplant 2009;28:1129-34. Copyright (C) 2009 by the International Society for Heart and Lung Transplantation. Copyright (C) 2009 by the International Society for Heart and Lung Transplantation.
Details
- Title: Subtitle
- Utility of Virtual Crossmatch in Sensitized Patients Awaiting Heart Transplantation
- Creators
- Josef Stehlik - University of Utah HospitalNauman Islam - University of Utah HospitalDenise Hurst - University of Utah HospitalAbdallah G. Kfoury - Intermountain Medical CenterMatthew A. Movsesian - VA Salt Lake City Healthcare SystemAnn Fuller - University of Utah HospitalJulio C. Delgado - University of Utah HospitalElizabeth H. Hammond - Intermountain HealthcareEdward M. Gilbert - University of Utah HospitalDale G. Renlund - Intermountain Medical CenterFeras Bader - University of Utah HospitalPatrick W. Fisher - Intermountain Medical CenterDavid A. Bull - University of Utah HospitalArun K. Singhal - University of Utah HospitalDavid D. Eckels - University of Utah Hospital
- Resource Type
- Journal article
- Publication Details
- The Journal of heart and lung transplantation, Vol.28(11), pp.1129-1134
- Publisher
- Elsevier
- DOI
- 10.1016/j.healun.2009.05.031
- PMID
- 19782589
- ISSN
- 1053-2498
- eISSN
- 1557-3117
- Number of pages
- 6
- Language
- English
- Date published
- 11/01/2009
- Academic Unit
- Cardiothoracic Surgery
- Record Identifier
- 9984322874502771
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